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Levetiracetam

Known as: (S)-alpha-Ethyl-2-oxo-1-pyrrolidineacetamide, 1-Pyrrolidineacetamide, Alpha-ethyl-2-oxo-,(S)-, etiracetam, S-isomer 
A pyrrolidine with antiepileptic activity. The exact mechanism through which levetiracetam exerts its effects is unknown but does not involve… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Background: Antiepileptic drugs (AEDs) are the mainstay of epilepsy treatment. Since 1989, 18 new AEDs have been licensed for… Expand
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Review
2017
Review
2017
Policy Points: Our study indicates that there are opportunities for cost savings in generic drug markets in Europe and the United… Expand
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Review
2017
Review
2017
Objective: We aimed to report the pattern of usage and efficacy of antiepileptic drugs (AEDs) in patients with autoimmune… Expand
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Highly Cited
2004
Highly Cited
2004
Here, we show that the synaptic vesicle protein SV2A is the brain binding site of levetiracetam (LEV), a new antiepileptic drug… Expand
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Review
2004
Review
2004
  • P. Patsalos
  • Clinical pharmacokinetics
  • 2004
  • Corpus ID: 34107693
Since 1989, eight new antiepileptic drugs (AEDs) have been licensed for clinical use. Levetiracetam is the latest to be licensed… Expand
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Highly Cited
2002
Highly Cited
2002
Summary:  Purpose: We investigated the effect of the new antiepileptic drug (AED) levetiracetam (LEV) on different types of high… Expand
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Highly Cited
2000
Highly Cited
2000
Objective: To evaluate the efficacy and safety of 500 mg bid and 1500 mg bid levetiracetam as adjunctive therapy for refractory… Expand
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Review
2000
Review
2000
  • P. Patsalos
  • Pharmacology & therapeutics
  • 2000
  • Corpus ID: 22495956
Levetiracetam is a novel orally active antiepileptic drug with a unique preclinical profile. It has a high therapeutic index and… Expand
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Highly Cited
2000
Highly Cited
2000
Summary: Purpose: To evaluate the efficacy and tolerability of levetiracetam (LEV, Keppra) as add‐on therapy in patients with… Expand
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Highly Cited
1998
Highly Cited
1998
The protective and adverse effect potentials of levetiracetam ((S)-alpha-ethyl-2-oxo-pyrrolidine acetamide) in rodent models of… Expand
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