Leukemic Hematopoietic Stem Cell

Known as: LSC, Leukemic Stem Cell 
A malignant hematopoietic cell which may derive from mutations in normal hematopoietic stem cells. Leukemic hematopoietic stem cells can initiate or… (More)
National Institutes of Health

Papers overview

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Review
2017
Review
2017
Chronic myeloid leukemia (CML) is caused by the acquisition of the tyrosine kinase BCR-ABL1 in a hemopoietic stem cell… (More)
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Review
2012
Review
2012
The cancer stem cell (CSC) model has been established as a cellular mechanism that contributes to phenotypic and functional… (More)
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Review
2009
Review
2009
The genetic events that contribute to the pathogenesis of acute myeloid leukemia are among the best characterized of all human… (More)
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Highly Cited
2008
Highly Cited
2008
Resistance of Bcr-Abl-positive leukemic stem cells (LSCs) to imatinib treatment in patients with chronic myeloid leukemia (CML… (More)
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Highly Cited
2007
Highly Cited
2007
Permanent cure of acute myeloid leukemia (AML) by chemotherapy alone remains elusive for most patients because of the inability… (More)
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Highly Cited
2005
Highly Cited
2005
Recent studies have described malignant stem cells as central to the initiation, growth, and potential relapse of acute and… (More)
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Highly Cited
2004
Highly Cited
2004
Emerging evidence suggests cancer stem cells sustain neoplasms; however, little is understood of the normal cell initially… (More)
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Highly Cited
2002
Highly Cited
2002
Acute myelogenous leukemia (AML) is typically a disease of stem progenitor cell origin. Interestingly, the leukemic stem cell… (More)
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Highly Cited
2001
Highly Cited
2001
The hematopoietic stem cell underlying acute myeloid leukemia (AML) is controversial. Flow cytometry and the DNA-binding dye… (More)
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Highly Cited
1997
Highly Cited
1997
On the subject of acute myeloid leukemia (AML), there is little consensus about the target cell within the hematopoietic stem… (More)
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