Leucine-Rich Repeat Serine/Threonine-Protein Kinase 2

Known as: Leucine-Rich Repeat Serine-Threonine Protein Kinase-2, Leucine Rich Repeat Serine Threonine Protein Kinase 2, Dardarin Protein 
A serine/threonine protein kinase with GTPase activity that contains 12 LEUCINE-rich repeats in its central region and 7 WD repeats C-terminal to its… (More)
National Institutes of Health

Papers overview

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2016
2016
Childhood acute myeloid leukemia; Mutation; TET2; KRAS; CBL; Next Generation Sequencing Abstract Background: Acute myeloid… (More)
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2016
2016
Leucine-rich repeat kinase 2 (LRRK2) kinase activity is increased in several pathogenic mutations, including the most common… (More)
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Highly Cited
2013
Highly Cited
2013
Recent genome-wide association studies indicate that a simple alteration of Leucine-rich repeat kinase 2 (LRRK2) gene expression… (More)
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2013
2013
Association studies have identified several signals at the LRRK2 locus for Parkinson's disease (PD), Crohn's disease (CD) and… (More)
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Highly Cited
2011
Highly Cited
2011
Mutations in leucine-rich repeat kinase 2 (LRRK2) cause late-onset Parkinson's disease (PD), but the underlying… (More)
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2008
2008
A hallmark of Parkinson's disease (PD) is the progressive loss of the A9 midbrain dopaminergic (mDA) neurons in the substantia… (More)
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2007
2007
BACKGROUND Pathogenic mutations in the leucine-rich repeat kinase 2 gene (LRRK2) have been found to cause typical, later-onset… (More)
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Highly Cited
2006
Highly Cited
2006
Mutations in the LRRK2 gene, coding for dardarin, cause dominantly inherited Parkinson's disease (PD). Dardarin is a large… (More)
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Review
2005
Review
2005
The past few years, mutations in 5 genes (a-synuclein, parkin, DJ-1, PINK1, and LRRK2) have been firmly implicated, and… (More)
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2005
2005
Mutations in the leucine-rich repeat kinase 2 (LRRK 2), encoding dardarin protein, have been demonstrated to be linked to… (More)
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