Laron Syndrome

Known as: Growth Hormone Receptor Defect, PITUITARY DWARFISM II, laron type dwarfism 
An autosomal recessive disorder characterized by short stature, defective GROWTH HORMONE RECEPTOR, and failure to generate INSULIN-LIKE GROWTH FACTOR… (More)
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2011
2011
The insulin/insulin-like growth factor-1 (IGF-1) pathway drives an evolutionarily conserved network that regulates lifespan and… (More)
  • figure 1
Is this relevant?
Highly Cited
2003
Highly Cited
2003
Activating mutations in FGF receptor 3 (FGFR3) cause several human dwarfism syndromes by affecting both chondrocyte proliferation… (More)
  • figure 1
  • figure 2
  • table I
  • table I
  • figure 3
Is this relevant?
Highly Cited
2002
Highly Cited
2002
Experimental and clinical studies suggest that GH and IGF-I may be involved in neovascularization of the retina in diabetes and… (More)
  • figure 2
Is this relevant?
Review
2001
Review
2001
AIM To contribute to the debate about whether growth hormone (GH) and insulin-like growth factor 1 (IGF-1) act independently on… (More)
  • figure 1
  • figure 2
  • figure 3
  • figure 4
  • figure 5
Is this relevant?
Highly Cited
2000
Highly Cited
2000
GH has many biological roles, including promotion of growth. Most, if not all, of its roles are achieved through interaction with… (More)
  • figure 1
  • figure 2
  • figure 3
  • table 2
  • figure 4
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Laron syndrome [growth hormone (GH) insensitivity syndrome] is a hereditary dwarfism resulting from defects in the GH receptor… (More)
  • figure 1
  • table 1
  • figure 2
  • figure 3
Is this relevant?
Review
1996
Review
1996
Since the original description of LS by Laron in 1966, this rare condition has continued to assume an importance far beyond the… (More)
Is this relevant?
1995
1995
Nine prepubertal children with Laron syndrome (6 males, 3 females) aged 0.5 to 14.6 years were treated by daily subcutaneous… (More)
Is this relevant?
1993
1993
Growth curves for children with Laron syndrome were constructed on the basis of repeated measurements made throughout infancy… (More)
  • figure 2
  • figure 3
  • figure 6
  • figure 5
Is this relevant?
Review
1991
Review
1991
PRL and GH are hormones with a wide spectrum of actions. Specific receptors are widely distributed in a number of classical… (More)
Is this relevant?