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Large granular lymphocyte

Known as: Large Granular Lymphocytes, granular large lymphocytes, LGL 
A population of large-sized lymphocytes found in human peripheral blood with slightly eccentric nuclei and abundant cytoplasmic azurophilic granules… Expand
National Institutes of Health

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Related topics

5 relations
Hematopoietic and Lymphoid TissueLymphocytes.large granular:NCnc:Pt:Bld:QnLymphocytes.large granular:PrThr:Pt:Bld:OrdLymphoid Tissue
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Papers overview

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Highly Cited
2010
Highly Cited
2010
Lgl, aPKC, and Crumbs Regulate the Salvador/Warts/Hippo Pathway through Two Distinct Mechanisms
BACKGROUND The Drosophila neoplastic tumor suppressor Lethal (2) giant larvae (Lgl) controls apicobasal cell polarity and… Expand
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Review
2008
Review
2008
Human natural killer cells.
Natural killer (NK) cells were discovered more than 30 years ago. NK cells are large granular lymphocytes that belong to the… Expand
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Highly Cited
2004
Highly Cited
2004
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells
Aggressive natural killer-cell leukemia (ANKL) is a rare form of large granular lymphocyte leukemia, which is characterized by a… Expand
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Highly Cited
2003
Highly Cited
2003
The Par complex directs asymmetric cell division by phosphorylating the cytoskeletal protein Lgl
To generate different cell types, some cells can segregate protein determinants into one of their two daughter cells during… Expand
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Review
2003
Review
2003
Clinical features of large granular lymphocyte leukemia.
The spectrum of large granular lymphocyte (LGL) proliferations consists of four distinct entities: reactive/transient LGL… Expand
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Highly Cited
2003
Highly Cited
2003
Mammalian Lgl Forms a Protein Complex with PAR-6 and aPKC Independently of PAR-3 to Regulate Epithelial Cell Polarity
BACKGROUND Epithelial cells have apicobasal polarity and an asymmetric junctional complex that provides the bases for development… Expand
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Highly Cited
2001
Highly Cited
2001
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.
Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytotoxic T lymphocytes. These… Expand
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Highly Cited
2000
Highly Cited
2000
Cooperative regulation of cell polarity and growth by Drosophila tumor suppressors.
Loss of cell polarity and tissue architecture are characteristics of malignant cancers derived from epithelial tissues. We… Expand
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Highly Cited
1986
Highly Cited
1986
The relationship of CD16 (Leu-11) and Leu-19 (NKH-1) antigen expression on human peripheral blood NK cells and cytotoxic T lymphocytes.
We examined the antigenic and functional characteristics of human peripheral blood lymphocytes that differentially express the… Expand
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Highly Cited
1981
Highly Cited
1981
Characteristics of human large granular lymphocytes and relationship to natural killer and K cells
Recent evidence, has demonstrated an association between a subpopulation of peripheral blood mononuclear cells, morphologically… Expand
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