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Large granular lymphocyte

Known as: Large Granular Lymphocytes, granular large lymphocytes, LGL 
A population of large-sized lymphocytes found in human peripheral blood with slightly eccentric nuclei and abundant cytoplasmic azurophilic granules… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1974-2017
05019742017

Related topics

Related topics

3 relations
Hematopoietic and Lymphoid TissueLymphoid TissueNatural Killer Cells

Related mentions per year

Related mentions per year

1936-2018
19401960198020002020
Large granular lymphocyte
Natural Killer Cells
Lymphoid Tissue
Hematopoietic and Lymphoid Tissue

Papers overview

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Highly Cited
2012
Highly Cited
2012
STAT3 mutations unify the pathogenesis of chronic lymphoproliferative disorders of NK cells and T-cell large granular lymphocyte leukemia.
Chronic lymphoproliferative disorders of natural killer cells (CLPD-NKs) and T-cell large granular lymphocytic leukemias (T-LGLs… (More)
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Highly Cited
2008
Highly Cited
2008
Network model of survival signaling in large granular lymphocyte leukemia.
T cell large granular lymphocyte (T-LGL) leukemia features a clonal expansion of antigen-primed, competent, cytotoxic T… (More)
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Highly Cited
2004
Highly Cited
2004
Aggressive natural killer-cell leukemia revisited: large granular lymphocyte leukemia of cytotoxic NK cells
Aggressive natural killer-cell leukemia (ANKL) is a rare form of large granular lymphocyte leukemia, which is characterized by a… (More)
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Highly Cited
2001
Highly Cited
2001
Inhibition of STAT3 signaling leads to apoptosis of leukemic large granular lymphocytes and decreased Mcl-1 expression.
Large granular lymphocyte (LGL) leukemia is characterized by the expansion of antigen-activated cytotoxic T lymphocytes. These… (More)
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2000
2000
Treatment of Large Granular Lymphocyte Leukemia With Oral Low-Dose Methotrexate
Morbidity and mortality in patients with T large granular lymphocyte (T-LGL) leukemia resutt from infections acquired during… (More)
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1998
1998
Dysregulation of CD95/CD95 ligand-apoptotic pathway in CD3(+) large granular lymphocyte leukemia.
CD95 (Fas)-induced apoptosis plays a critical role in the elimination of activated lymphocytes and induction of peripheral… (More)
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Highly Cited
1996
Highly Cited
1996
Fas ligand in human serum
The Fas ligand (FasL), a member of the tumor necrosis factor family, induces apoptosis in Fas–bearing cells. The membrane–bound… (More)
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Highly Cited
1995
Highly Cited
1995
Cloning and functional characteristics of murine large granular lymphocyte-1: a member of the Ly-49 gene family (Ly-49G2)
Large granular lymphocyte (LGL) 1 is a cell surface glycoprotein expressed on a subset (50%) of C57BL/6 natural killer (NK) cells… (More)
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Highly Cited
1984
Highly Cited
1984
Cytolytic activity of purified cytoplasmic granules from cytotoxic rat large granular lymphocyte tumors
Purified cytoplasmic granules from cytotoxic rat large granular lymphocytes (LGL) tumors were cytolytic to erythrocytes… (More)
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Highly Cited
1981
Highly Cited
1981
Characteristics of human large granular lymphocytes and relationship to natural killer and K cells
Recent evidence, has demonstrated an association between a subpopulation of peripheral blood mononuclear cells, morphologically… (More)
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