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LY395756

 
National Institutes of Health

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2017
2017
Juvenile treatment with a novel mGluR2 agonist/mGluR3 antagonist compound, LY395756, reverses learning deficits and cognitive flexibility impairments in adults in a neurodevelopmental model of…
&NA; Schizophrenia (SCZ) is a neurodevelopmental psychiatric disorder, in which cognitive function becomes disrupted at early… Expand
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2015
2015
LY395756, an mGluR2 agonist and mGluR3 antagonist, enhances NMDA receptor expression and function in the normal adult rat prefrontal cortex, but fails to improve working memory and reverse MK801…
Targeting group II metabotropic glutamate receptors (mGluR2/3) has been proposed to correct the dysfunctional glutamatergic… Expand
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2014
2014
Age-dependent Effects of mGluR2 Agonist LY395756 on NMDA Receptor Expression and Function in the Rat Prefrontal Cortex
 
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2013
2013
Group II Metabotropic Glutamate Receptor Agonist LY379268 Regulates AMPA Receptor Trafficking in Prefrontal Cortical Neurons
Group II metabotropic glutamate receptor (mGluR) agonists have emerged as potential treatment drugs for schizophrenia and other… Expand
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2013
2013
Selective activation of either mGlu2 or mGlu3 receptors can induce LTD in the amygdala
Group II metabotropic glutamate (mGlu) receptors are known to induce a long-term depression (LTD) of synaptic transmission in… Expand
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2011
2011
Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 receptor expression in a Wistar substrain with an anxiety-like phenotype.
Group II metabotropic receptors (mGluRs) regulate central synaptic transmission by modulating neurotransmitter release. However… Expand
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