LY 231617

Activation of transcription factor nuclear factor-κB (NF-κB) can result in enhanced de novo synthesis of both proteins that… Expand

The role of reactive oxygen species in the pathogenesis of the neurotoxicity associated with ischemia-reperfusion, was… Expand

Abstract : The compound LY231617 {2,6‐bis(1,1‐dimethylethyl)‐4‐[[(1‐ethyl)amino]methyl]phenol hydrochloride} has been reported to… Expand

BACKGROUND AND PURPOSE Nuclear factor-kappaB (NF-kappaB) is an oxidative stress responsive transcription factor that is… Expand

Lipid peroxidation is a major consequence of oxidative stress and an important cause of neuronal damage in ischaemic injuries and… Expand

Recent studies have shown that the novel antioxidant LY231617 protects against ischaemia-induced neuronal damage in rat models of… Expand

BACKGROUND: Reactive oxygen species may mediate tissue injury in inflammatory bowel disease. Aminosalicylates have antioxidant… Expand

The antioxidant LY231617 has previously been shown to offer significant protection against postischemic cell death in the… Expand

In this study the effect of LY 231617, an antioxidant, on spatial learning deficit and on neuronal damage following transient… Expand

Background and Purpose In the rat four-vessel occlusion model with 30 minutes of ischemia most agents have failed to be of… Expand