LY 231617

Activation of transcription factor nuclear factor-κB (NF-κB) can result in enhanced de novo synthesis of both proteins that… (More)

The role of reactive oxygen species in the pathogenesis of the neurotoxicity associated with ischemia-reperfusion, was… (More)

BACKGROUND AND PURPOSE Nuclear factor-kappaB (NF-kappaB) is an oxidative stress responsive transcription factor that is… (More)

Lipid peroxidation is a major consequence of oxidative stress and an important cause of neuronal damage in ischaemic injuries and… (More)

Recent studies have shown that the novel antioxidant LY231617 protects against ischaemia-induced neuronal damage in rat models of… (More)

Global cerebral ischemia leads to selective neuronal damage in the CA1 sector of the hippocampus and in the striatum. This… (More)

BACKGROUND Reactive oxygen species may mediate tissue injury in inflammatory bowel disease. Aminosalicylates have antioxidant… (More)

The antioxidant LY231617 has previously been shown to offer significant protection against postischemic cell death in the… (More)

In this study the effect of LY 231617, an antioxidant, on spatial learning deficit and on neuronal damage following transient… (More)

BACKGROUND AND PURPOSE In the rat four-vessel occlusion model with 30 minutes of ischemia most agents have failed to be of… (More)