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Amino acid Asp-351 in the ligand binding domain of estrogen receptor α (ERα) plays an important role in regulating the estrogen… Expand Since the description of the first antioestrogen, MER 25, more than four decades ago (Lerner et al. 1958), and of tamoxifen ten… Expand It is imperative to develop new agents for the prevention of breast cancer, considering the incidence of this disease and its… Expand Estrogen or raloxifene (LY156758) prevent estrogen deficiency-induced bone loss in animals and humans. We demonstrated in the rat… Expand Fourteen patients with disseminated breast cancer with primary or secondary resistance to tamoxifen were treated with LY156758… Expand We have examined the effect of androst-5-ene-3 beta,17 beta-diol (delta 5-diol) and its precursors, dehydroepiandrosterone (DHEA… Expand Estradiol amplified synergistically the dose- and time-dependent stimulatory actions of human somatomedin-C on progesterone… Expand Endocrine therapy with estrogen deprivation or with antiestrogens results in tumor regression in a subset of patients with… Expand In an effort to prepare nonsteroidal antiestrogens demonstrating greater antagonism and less intrinsic estrogenicity than those… Expand Keoxifene (LY156758) is a new benzothiophene-derived antiestrogen with an extremely low degree of estrogenicity. Administration… Expand