Skip to search formSkip to main contentSkip to account menu

LTA4H wt Allele

Known as: LTA4, Leukotriene A4 Hydrolase wt Allele 
Human LTA4H wild-type allele is located in the vicinity of 12q22 and is approximately 43 kb in length. This allele, which encodes leukotriene A-4… 
National Institutes of Health

Related topics

Related topics

5 relations
12q22Arachidonic Acid Metabolism PathwayEicosanoid ModulationHydrolysis

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2015
2015
Pro-Resolving Maresins in Inflammation: New Pathway and Mechanisms With Oral Pathogens
2007
2007
Development of a Homogeneous Time-Resolved Fluorescence Leukotriene B4 Assay for Determining the Activity of Leukotriene A4 Hydrolase
Leukotriene A4 (LTA4) hydrolase catalyzes a rate-limiting final biosynthetic step of leukotriene B4 (LTB4), a potent lipid… 
1999
1999
Gene expression of 5‐lipoxygenase and LTA4 hydrolase in renal tissue of nephrotic syndrome patients
Leukotrienes (LT) of the 5‐lipoxygenase pathway constitute a class of potent biological lipid mediators of inflammation… 
1999
1999
Mouse leukotriene A4 hydrolase is expressed at high levels in intestinal crypt cells and splenic lymphocytes.
1998
1998
Human large luteal cells in the menstrual cycle and early pregnancy express leukotriene A4 hydrolase.
Leukotriene (LT) A4 hydrolase (EC3.3.2.6) converts LTA4 to LTB4 which shows a chemotactic activity to leukocytes. To investigate… 
1996
1996
LTA4 hydrolase in human skin: decreased activity, but normal concentration in lesional psoriatic skin
Leukotriene A4 (LTA4) hydrolase which transforms LTA4 into the proinflammatory compound LTB4 has been identified in human… 
1996
1996
The human leukotriene A4 hydrolase gene is expressed in two alternatively spliced mRNA forms.
We identified a novel short (s-) mRNA of the human leukotriene-A4 (LTA4) hydrolase using sequential reverse transcriptase PCR… 
1993
1993
Identification of 5-keto-(7E,9E,11Z,14Z)-eicosatetraenoic acid as a novel nonenzymatic rearrangement product of leukotriene A4.
Leukotriene A4 (LTA4), the reaction product of 5-lipoxygenase in human polymorphonuclear (PMN) leukocytes, is transformed both to… 
1992
1992
Leukotriene A4 hydrolase, a bifunctional enzyme Distinction of leukotriene A4 hydrolase and aminopeptidase activities by site‐directed mutagenesis at Glu‐297
Review
1985
Review
1985
Substrate and regulatory functions of eicosapentaenoic and docosahexaenoic acids for the 5-lipoxygenase pathway. Implications for pulmonary responses.
Arachidonic acid (AA) released from membrane phospholipids by phospholipases during cell activation may be oxidatively… 
By clicking accept or continuing to use the site, you agree to the terms outlined in our Privacy Policy (opens in a new tab), Terms of Service (opens in a new tab), and Dataset License (opens in a new tab)