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LRRK2-IN1

Known as: LRRK2-IN-1 
National Institutes of Health

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2 relations

Broader (2)

BenzodiazepinonesPyrimidines

Papers overview

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Highly Cited
2019
Highly Cited
2019
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
Mutations of LRRK2, encoding leucine-rich repeat kinase 2 (LRRK2), are the leading cause of autosomal dominant Parkinson's… 
2018
2018
LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD). The… 
Highly Cited
2015
Highly Cited
2015
Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition
It has been uncertain whether specific disease-relevant biomarker phenotypes can be found using sporadic Parkinson’s disease (PD… 
Highly Cited
2014
Highly Cited
2014
The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson’s disease, and its inhibition… 
Highly Cited
2014
Highly Cited
2014
Phosphoproteomic evaluation of pharmacological inhibition of leucine‐rich repeat kinase 2 reveals significant off‐target effects of LRRK‐2‐IN‐1
Genetic mutations in leucine‐rich repeat kinase 2 (LRRK2) have been linked to autosomal dominant Parkinson's disease. The most… 
Highly Cited
2013
Highly Cited
2013
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
A cluster of phosphorylation sites in LRRK2 (leucine-rich repeat kinase 2), including Ser910, Ser935, Ser955 and Ser973, is… 
Highly Cited
2013
Highly Cited
2013
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Parkinson's disease (PD). To… 
Highly Cited
2013
Highly Cited
2013
Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration
Highly Cited
2012
Highly Cited
2012
Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition
J. Neurochem. (2012) 120, 37–45. 
Highly Cited
2011
Highly Cited
2011
Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2
Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson’s disease… 
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