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LRRK2-IN1
Known as:
LRRK2-IN-1
National Institutes of Health
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Related topics
Related topics
2 relations
Broader (2)
Benzodiazepinones
Pyrimidines
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2019
Highly Cited
2019
LRRK2 impairs PINK1/Parkin-dependent mitophagy via its kinase activity: pathologic insights into Parkinson's disease.
F. Bonello
,
S. Hassoun
,
+9 authors
O. Corti
Human Molecular Genetics
2019
Corpus ID: 58553386
Mutations of LRRK2, encoding leucine-rich repeat kinase 2 (LRRK2), are the leading cause of autosomal dominant Parkinson's…
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2018
2018
LRRK2 G2019S Induces Anxiety/Depression-like Behavior before the Onset of Motor Dysfunction with 5-HT1A Receptor Upregulation in Mice
Juhee Lim
,
Yeojin Bang
,
+4 authors
H. Choi
Journal of Neuroscience
2018
Corpus ID: 46803682
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are the most common genetic cause of Parkinson's disease (PD). The…
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Highly Cited
2015
Highly Cited
2015
Fibroblast Biomarkers of Sporadic Parkinson’s Disease and LRRK2 Kinase Inhibition
G. A. Smith
,
J. Jansson
,
E. M. Rocha
,
T. Osborn
,
P. Hallett
,
O. Isacson
Molecular Neurobiology
2015
Corpus ID: 3602305
It has been uncertain whether specific disease-relevant biomarker phenotypes can be found using sporadic Parkinson’s disease (PD…
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Highly Cited
2014
Highly Cited
2014
The LRRK2 inhibitor GSK2578215A induces protective autophagy in SH-SY5Y cells: involvement of Drp-1-mediated mitochondrial fission and mitochondrial-derived ROS signaling
S. Sáez-Atienzar
,
L. Bonet-Ponce
,
+4 authors
M. Galindo
Cell Death and Disease
2014
Corpus ID: 9316510
Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene have been associated with Parkinson’s disease, and its inhibition…
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Highly Cited
2014
Highly Cited
2014
Phosphoproteomic evaluation of pharmacological inhibition of leucine‐rich repeat kinase 2 reveals significant off‐target effects of LRRK‐2‐IN‐1
Greg Luerman
,
C. Nguyen
,
+9 authors
W. Hirst
Journal of Neurochemistry
2014
Corpus ID: 35263991
Genetic mutations in leucine‐rich repeat kinase 2 (LRRK2) have been linked to autosomal dominant Parkinson's disease. The most…
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Highly Cited
2013
Highly Cited
2013
Identification of protein phosphatase 1 as a regulator of the LRRK2 phosphorylation cycle.
E. Lobbestael
,
Jing Zhao
,
+9 authors
J. Taymans
Biochemical Journal
2013
Corpus ID: 13792166
A cluster of phosphorylation sites in LRRK2 (leucine-rich repeat kinase 2), including Ser910, Ser935, Ser955 and Ser973, is…
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Highly Cited
2013
Highly Cited
2013
Kinase inhibitors arrest neurodegeneration in cell and C. elegans models of LRRK2 toxicity.
Chen Yao
,
W. M. Johnson
,
+9 authors
Shu G. Chen
Human Molecular Genetics
2013
Corpus ID: 13910782
Mutations in leucine-rich repeat kinase 2 (LRRK2) are the most frequent known cause of late-onset Parkinson's disease (PD). To…
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Highly Cited
2013
Highly Cited
2013
Leucine-rich repeat kinase 2 functionally interacts with microtubules and kinase-dependently modulates cell migration
M. Caesar
,
S. Zach
,
C. Carlson
,
K. Brockmann
,
T. Gasser
,
F. Gillardon
Neurobiology of Disease
2013
Corpus ID: 35972214
Highly Cited
2012
Highly Cited
2012
Phosphorylation of LRRK2 serines 955 and 973 is disrupted by Parkinson’s disease mutations and LRRK2 pharmacological inhibition
Elizabeth A. Doggett
,
Jing Zhao
,
Christina N. Mork
,
D. Hu
,
R. Nichols
Journal of Neurochemistry
2012
Corpus ID: 20685555
J. Neurochem. (2012) 120, 37–45.
Highly Cited
2011
Highly Cited
2011
Characterization of a selective inhibitor of the Parkinson’s disease kinase LRRK2
Xianming Deng
,
N. Dzamko
,
+8 authors
N. Gray
Nature Chemical Biology
2011
Corpus ID: 5590941
Mutations in leucine-rich repeat kinase 2 (LRRK2) are strongly associated with late-onset autosomal dominant Parkinson’s disease…
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