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LOXO-101

Known as: Trk Inhibitor LOXO-101 
An orally available, tropomyosin receptor kinase (Trk) inhibitor, with potential antineoplastic activity. Upon administration, LOXO-101 binds to Trk… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
One of the most challenging issues in oncology research and treatment is identifying oncogenic drivers within an individual… Expand
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Review
2018
Review
2018
Precision medicine just witnessed two breakthroughs in oncology in 2017. Pembrolizumab (Keytruda), Merck’s anti-programmed cell… Expand
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Highly Cited
2017
Highly Cited
2017
LBA2501Background: Larotrectinib is the first selective small-molecule pan-TRK inhibitor. TRK fusions appear oncogenic… Expand
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Review
2017
Review
2017
&NA; The tropomyosin receptor kinase (TRK) family includes TRKA, TRKB, and TRKC proteins, which are encoded by NTRK1, NTRK2 and… Expand
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2017
2017
Neurotrophic receptor tyrosine kinase 1 (NTRK1) gene rearrangement leads to constitutive activation of NTRK1, which induces high… Expand
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Highly Cited
2016
Highly Cited
2016
Infantile fibrosarcoma (IFS) is a rare pediatric cancer typically presenting in the first 2 years of life. Surgical resection is… Expand
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2016
2016
Background: NTRK1, 2 and 3 gene fusions occur across a wide array of tumor types and can lead to constitutively-active TRKA, B… Expand
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Highly Cited
2015
Highly Cited
2015
UNLABELLED Oncogenic TRK fusions induce cancer cell proliferation and engage critical cancer-related downstream signaling… Expand
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2015
2015
Background LOXO-101 is the first highly selective and potent small-molecule inhibitor of TRKA, TRKB, and TRKC to be dosed… Expand
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2015
2015
TPS2624 Background: TheTRK family of neurotrophin receptors, TRKA, TRKB, and TRKC (encoded by NTRK1, NTRK2, and NTRK3 genes… Expand
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