FAQ

LEPTIN DEFICIENCY OR DYSFUNCTION

Known as: LEPD, Leptin Deficiency, OBESITY, MORBID, NONSYNDROMIC 1 
Deficiency of the adipose tissue-derived peptide hormone leptin, associated with loss-of-function mutation(s) in the LEP gene.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2018
012319902018

Related topics

Related topics

5 relations
Autosomal recessive inheritanceGynecomastiaHypogonadismPrimary physiologic amenorrhea
(More)

Related mentions per year

Related mentions per year

1937-2018
19401960198020002020
LEPTIN DEFICIENCY OR DYSFUNCTION
Autosomal recessive inheritance
Hypogonadism
Gynecomastia
Primary physiologic amenorrhea
Recurrent upper respiratory tract infection

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
Neonatal Growth Restriction-Related Leptin Deficiency Enhances Leptin-Triggered Sympathetic Activation and Central Angiotensin II Receptor-Dependent Stress-Evoked Hypertension
Background:Neonatal growth restriction (nGR) leads to leptin deficiency and increases the risk of hypertension. Previous studies… (More)
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Review
2016
Review
2016
Role of Leptin Deficiency, Inefficiency, and Leptin Receptors in Obesity
Leptin protein consists of 167 amino acids, which is mainly secreted from the white adipose tissue. This protein acts on the… (More)
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2015
2015
Leptin Deficiency Shifts Mast Cells toward Anti-Inflammatory Actions and Protects Mice from Obesity and Diabetes by Polarizing M2 Macrophages.
Mast cells (MCs) contribute to the pathogenesis of obesity and diabetes. This study demonstrates that leptin deficiency slants… (More)
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2014
2014
Leptin deficiency impairs maturation of dendritic cells and enhances induction of regulatory T and Th17 cells.
Leptin is an adipose-secreted hormone that plays an important role in both metabolism and immunity. Leptin has been shown to… (More)
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2012
2012
Effects of Leptin Deficiency and Replacement on Cerebellar Response to Food-Related Cues
Leptin affects eating behavior partly by altering the response of the brain to food-related stimuli. The effects of leptin on… (More)
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2012
2012
Leptin Deficiency and Its Effects on Tibial and Vertebral Bone Mechanical Properties in Mature Genetically Lean and Obese JCR:LA-Corpulent Rats
Leptin signaling deficient rodents have emerged as models of obesity/insulin resistance syndrome. Altered leptin signaling… (More)
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2010
2010
Leptin Deficiency Causes Insulin Resistance Induced by Uncontrolled Diabetes
OBJECTIVE Depletion of body fat stores during uncontrolled, insulin-deficient diabetes (uDM) results in markedly reduced plasma… (More)
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1996
1996
[Clinical study on the effect of TCM treatment in decreasing frequency of peritoneal dialysis].
  • D. Guo, J. Yu
  • Zhongguo Zhong xi yi jie he za zhi Zhongguo…
  • 1996
Traditional Chinese herbal medicine was used in combination with peritoneal dialysis (PD) in order to improve the renal function… (More)
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Review
1994
Review
1994
True-coincidence correction when using an LEPD for the determination of the lanthanides in the environment via K0-based INAA
As part of a recent study on the environmental effects caused by the operation of a coal-fired power station at Sines, Portugal… (More)
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1990
1990
CADEIA and REJECT. Codes to compute relevant gamma-gamma and gamma-X true-coincidence lines in absolute counting of gamma rays with a LEPD.
CADEIA and REJECT are computer codes for generating gamma-gamma and gamma-X true-coincidence lines for calculation of correction… (More)
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