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LEPTIN DEFICIENCY OR DYSFUNCTION

Known as: LEPD, LEPTIN DEFICIENCY, OBESITY, MORBID, NONSYNDROMIC 1 
Deficiency of the adipose tissue-derived peptide hormone leptin, associated with loss-of-function mutation(s) in the LEP gene.
National Institutes of Health

Papers overview

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2009
2009
OBJECTIVE To evaluate the associations between leptinemia and the components of metabolic syndrome (MetS). METHODS Fifty-one… 
Highly Cited
2005
Highly Cited
2005
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response… 
2004
2004
It is known that, among human patients with sepsis, acute renal failure (ARF) dramatically increases mortality rates to 50 to 80… 
Highly Cited
2003
Highly Cited
2003
To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor‐deficient Zucker rat was… 
Highly Cited
2003
Highly Cited
2003
Leptin may influence RA in opposing ways: enhance the expression of Th1 cytokines or limit the inflammatory responses Leptin is… 
Highly Cited
1999
Highly Cited
1999
The limited information on serum leptin levels in elderly men suggests the occurrence of an age‐related decrease, with disruption… 
1999
1999
OBJECTIVE There is considerable interest in how to prevent weight gain in adulthood. Leptin, a peptide hormone expressed in… 
Review
1998
Review
1998
Following the initial confirmation of the existence of leptin in humans by Friedman and his colleagues (Zhang et al. I994), many…