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LEPTIN DEFICIENCY OR DYSFUNCTION
Known as:
LEPD
, LEPTIN DEFICIENCY
, OBESITY, MORBID, NONSYNDROMIC 1
Deficiency of the adipose tissue-derived peptide hormone leptin, associated with loss-of-function mutation(s) in the LEP gene.
National Institutes of Health
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Related topics
Related topics
6 relations
Autosomal recessive inheritance
Gynecomastia
Hypogonadism
Primary physiologic amenorrhea
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Growth restriction, leptin, and the programming of adult behavior in mice
Lauritz R. Meyer
,
V. Zhu
,
Alise K. Miller
,
R. Roghair
Behavioural Brain Research
2014
Corpus ID: 8455759
2009
2009
Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome.
G. Paz-Filho
,
A. Volaco
,
H. Suplicy
,
R. Radominski
,
C. Boguszewski
Arquivos brasileiros de endocrinologia e…
2009
Corpus ID: 916468
OBJECTIVE To evaluate the associations between leptinemia and the components of metabolic syndrome (MetS). METHODS Fifty-one…
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Highly Cited
2005
Highly Cited
2005
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal.
J. Montez
,
A. Soukas
,
E. Asilmaz
,
Gulnorakhon Fayzikhodjaeva
,
G. Fantuzzi
,
J. Friedman
Proceedings of the National Academy of Sciences…
2005
Corpus ID: 998677
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response…
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2004
2004
Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice.
Wei Wang
,
B. Poole
,
+4 authors
R. Schrier
Journal of the American Society of Nephrology
2004
Corpus ID: 12779169
It is known that, among human patients with sepsis, acute renal failure (ARF) dramatically increases mortality rates to 50 to 80…
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Highly Cited
2003
Highly Cited
2003
Characterization of Bone Structure in Leptin Receptor‐Deficient Zucker (fa/fa) Rats
J. Tamasi
,
B. Arey
,
D. Bertolini
,
J. Feyen
Journal of Bone and Mineral Research
2003
Corpus ID: 7026532
To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor‐deficient Zucker rat was…
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Highly Cited
2003
Highly Cited
2003
A role for leptin in rheumatic diseases?
G. Palmer
,
C. Gabay
Annals of the Rheumatic Diseases
2003
Corpus ID: 36404337
Leptin may influence RA in opposing ways: enhance the expression of Th1 cytokines or limit the inflammatory responses Leptin is…
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2003
2003
Gallbladder motility in agouti-yellow and leptin-resistant obese mice.
K. Tran
,
D. Swartz-Basile
,
A. Nakeeb
,
H. Pitt
Journal of Surgical Research
2003
Corpus ID: 20432034
Highly Cited
1999
Highly Cited
1999
Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency?
Jan K. Van den Saffele
,
S. Goemaere
,
D. De Bacquer
,
J. Kaufman
Clinical Endocrinology
1999
Corpus ID: 23201912
The limited information on serum leptin levels in elderly men suggests the occurrence of an age‐related decrease, with disruption…
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1999
1999
Serum leptin and weight gain over 8 years in African American and Caucasian young adults.
A. Folsom
,
M. Jensen
,
D. Jacobs
,
J. Hilner
,
A. Tsai
,
P. Schreiner
Obesity Research
1999
Corpus ID: 19468665
OBJECTIVE There is considerable interest in how to prevent weight gain in adulthood. Leptin, a peptide hormone expressed in…
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Review
1998
Review
1998
Leptin production in human adipose tissue
S. Coppack
,
Jonathan Pinkney
,
V. Mohamed-ali
Proceedings of the Nutrition Society
1998
Corpus ID: 7139208
Following the initial confirmation of the existence of leptin in humans by Friedman and his colleagues (Zhang et al. I994), many…
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