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LEPTIN DEFICIENCY OR DYSFUNCTION

Known as: LEPD, LEPTIN DEFICIENCY, OBESITY, MORBID, NONSYNDROMIC 1 
Deficiency of the adipose tissue-derived peptide hormone leptin, associated with loss-of-function mutation(s) in the LEP gene.
National Institutes of Health

Related topics

Related topics

6 relations
Autosomal recessive inheritanceGynecomastiaHypogonadismPrimary physiologic amenorrhea

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2014
2014
Growth restriction, leptin, and the programming of adult behavior in mice
2009
2009
Decrease in leptin production by the adipose tissue in obesity associated with severe metabolic syndrome.
OBJECTIVE To evaluate the associations between leptinemia and the components of metabolic syndrome (MetS). METHODS Fifty-one… 
Highly Cited
2005
Highly Cited
2005
Acute leptin deficiency, leptin resistance, and the physiologic response to leptin withdrawal.
Food restriction and weight loss result in reduced plasma leptin, which is associated with a pleiotropic biologic response… 
2004
2004
Role of leptin deficiency in early acute renal failure during endotoxemia in ob/ob mice.
It is known that, among human patients with sepsis, acute renal failure (ARF) dramatically increases mortality rates to 50 to 80… 
Highly Cited
2003
Highly Cited
2003
Characterization of Bone Structure in Leptin Receptor‐Deficient Zucker (fa/fa) Rats
To investigate the role of leptin in bone formation, the skeleton of the obese female leptin receptor‐deficient Zucker rat was… 
Highly Cited
2003
Highly Cited
2003
A role for leptin in rheumatic diseases?
Leptin may influence RA in opposing ways: enhance the expression of Th1 cytokines or limit the inflammatory responses Leptin is… 
2003
2003
Gallbladder motility in agouti-yellow and leptin-resistant obese mice.
Highly Cited
1999
Highly Cited
1999
Serum leptin levels in healthy ageing men: are decreased serum testosterone and increased adiposity in elderly men the consequence of leptin deficiency?
The limited information on serum leptin levels in elderly men suggests the occurrence of an age‐related decrease, with disruption… 
1999
1999
Serum leptin and weight gain over 8 years in African American and Caucasian young adults.
OBJECTIVE There is considerable interest in how to prevent weight gain in adulthood. Leptin, a peptide hormone expressed in… 
Review
1998
Review
1998
Leptin production in human adipose tissue
Following the initial confirmation of the existence of leptin in humans by Friedman and his colleagues (Zhang et al. I994), many… 
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