LCP1 protein, human

Known as: Lymphocyte Cytosol Polypeptide 64-KD, L-Plastin, Lymphocyte Cytosolic Protein 1 
Plastin-2 (627 aa, ~70 kDa) is encoded by the human LCP1 gene. This protein is involved in both actin binding and T-cell activation.
National Institutes of Health

Topic mentions per year

Topic mentions per year

1990-2018
051019902018

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2010
2010
Engagement of TCRs induces actin rearrangements, which are critical for T cell activation. T cell responses require new actin… (More)
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2008
2008
Many actin binding proteins have a modular architecture, and calponin-homology (CH) domains are one such structurally conserved… (More)
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2006
2006
L-plastin, a malignant transformation-associated protein, is a member of a large family of actin filament cross-linkers. Here, we… (More)
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Highly Cited
1999
Highly Cited
1999
The entry of Salmonella typhimurium into nonphagocytic cells requires a panel of bacterial effector proteins that are delivered… (More)
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Highly Cited
1998
Highly Cited
1998
Regulation of leukocyte integrin avidity is a crucial aspect of inflammation and immunity. The actin cytoskeleton has an… (More)
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1995
1995
Shigella flexneri is an enteroinvasive bacterium which causes bacillary dysentery in humans. A major feature of its pathogenic… (More)
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1994
1994
Fimbrins/plastins are a family of highly conserved actin-bundling proteins. They are present in all eukaryotic cells including… (More)
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1994
1994
The complete cDNA sequence of human intestine-specific plastin (I-plastin) was determined from a clone derived by PCR. It… (More)
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1992
1992
The amino acid sequences deduced from cDNA analyses revealed that human leucocyte L-plastin phosphorylated in response to… (More)
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Highly Cited
1990
Highly Cited
1990
Fimbrin is an actin-bundling protein found in intestinal microvilli, hair cell stereocilia, and fibroblast filopodia. The… (More)
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