L-leucyl-L-leucine methyl ester

Known as: LLME, LeuLeuOMe 
A 2-amino acid compound with immunomodulatory activity. L-leucyl-L-leucine methyl ester (LLME) is a lysosomotropic agent entering cells via receptor… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1987-2016
051019872016

Papers overview

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2017
2017
L-leucyl-L-leucine methyl ester (LLOMe) induces apoptosis, which is thought to be mediated by release of lysosomal cysteine… (More)
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Highly Cited
2008
Highly Cited
2008
As a model for defining the role of lysosomal cathepsins in apoptosis, we characterized the action of the lysosomotropic agent… (More)
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Highly Cited
2004
Highly Cited
2004
Increasing evidence suggests that lysosomal proteases are actively involved in apoptosis. Using HeLa cells as the model system… (More)
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1999
1999
Lysosomes are fundamental for cell growth, and thus inhibition of the lysosomal function often leads to cell death. L-Leucyl-L… (More)
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1996
1996
L-Leucyl-L-leucine methyl ester (Leu-Leu-OMe), an apoptosis inducer in natural killer cells and macrophages, was caged with trans… (More)
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1995
1995
L-Leucyl-L-leucine methyl ester (LLME) is a lysosomatropic compound that is converted by dipeptidyl peptidase I to metabolites… (More)
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1995
1995
In this study, we newly synthesized caged compounds of L-leucyl-L-leucine methyl ester and examined their photochemical and… (More)
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1992
1992
Previous studies have demonstrated that the selective toxicity of leucyl-leucine methyl ester (Leu-Leu-OMe) for cytotoxic… (More)
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1991
1991
L-leucyl-L-leucine methyl ester (LLME) is a lysosomotropic agent that in microMolar concentrations has been found to be… (More)
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1987
1987
L-leucyl-L-leucine methyl ester (Leu-Leu-OMe) is selectively toxic for human natural killer (NK) cells and cytotoxic T… (More)
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