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Bone metastasis from breast and prostate carcinomas is facilitated by activation of bone-resorbing osteoclasts. Using proteomics… Expand Sealing ring formation is a requirement for osteoclast function. We have recently identified the role of an actin-bundling… Expand The function of the extracellular matrix (ECM) in the tumor microenvironment is not limited to forming a barrier against tumor… Expand Podosomes are cellular structures acting as degradation ‘hot-spots’ in monocytic cells. They appear as dot-like structures at the… Expand Chemokines such as SDF-1α play a crucial role in orchestrating T lymphocyte polarity and migration via polymerization and… Expand Activation of naïve T cells requires costimulation via TCR/CD3 plus accessory receptors, which enables the dynamic rearrangement… Expand The aim of this study is to identify the exact mechanism(s) by which cytoskeletal structures are modulated during bone resorption… Expand We investigated the coupling of the fMLP (N -formyl-L-methionyl-L-leucyl-L-phenylalanine; 'chemotactic peptide') receptor with… Expand Regulation of leukocyte integrin avidity is a crucial aspect of inflammation and immunity. The actin cytoskeleton has an… Expand L-Plastin is a calcium-regulated actin bundling protein expressed in leukocytes and some transformed cells, which is… Expand