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L 822429
Known as:
L-822429
, L822429
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala
S. Khom
,
T. Steinkellner
,
T. Hnasko
,
M. Roberto
Science Advances
2020
Corpus ID: 214628739
Alcohol dependence induces hypersensitivity of the SP/NK-1R system and its regulation of CeA inhibitory transmission. Behavioral…
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2018
2018
The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models
M. K. Sequeira
,
B. Nelson
,
+7 authors
J. Schank
Neuropharmacology
2018
Corpus ID: 21729654
2015
2015
Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking
J. Schank
,
B. Nelson
,
+7 authors
M. Heilig
Neuropharmacology
2015
Corpus ID: 22853231
2015
2015
Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats
L. Ayanwuyi
,
Serena Stopponi
,
+8 authors
R. Ciccocioppo
British Journal of Pharmacology
2015
Corpus ID: 38135966
Substance P and its preferred neurokinin receptor NK1 have been implicated in stress and anxiety and have been proposed as…
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2014
2014
The Role of the Neurokinin-1 Receptor in Stress-Induced Reinstatement of Alcohol and Cocaine Seeking
J. Schank
,
C. King
,
+5 authors
J. Schroeder
Neuropsychopharmacology
2014
Corpus ID: 24446381
Neurokinin-1 receptors (NK1Rs) have been shown to mediate alcohol and opiate, but not cocaine reward in rodents. We recently…
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2013
2013
The NK1 Receptor Antagonist L822429 Reduces Heroin Reinforcement
E. Barbier
,
L. Vendruscolo
,
+10 authors
M. Heilig
Neuropsychopharmacology
2013
Corpus ID: 20011643
Genetic deletion of the neurokinin 1 receptor (NK1R) has been shown to decrease the reinforcing properties of opioids, but it is…
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2013
2013
Tacr1 Gene Variation and Neurokinin 1 Receptor Expression Is Associated with Antagonist Efficacy in Genetically Selected Alcohol-Preferring Rats
J. Schank
,
J. Tapocik
,
+12 authors
M. Heilig
Biological Psychiatry
2013
Corpus ID: 13786268
Highly Cited
2011
Highly Cited
2011
Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429
J. Schank
,
C. Pickens
,
+5 authors
M. Heilig
Psychopharmacology
2011
Corpus ID: 25038819
RationaleGenetic inactivation or pharmacological antagonism of neurokinin 1 (NK1) receptors blocks morphine and alcohol reward in…
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2011
2011
A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment
S. Gaburro
,
O. Stiedl
,
P. Giusti
,
S. Sartori
,
R. Landgraf
,
N. Singewald
International Journal of Neuropsychopharmacology
2011
Corpus ID: 16705441
Increasing evidence suggests that specific physiological measures may serve as biomarkers for successful treatment to alleviate…
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Highly Cited
2008
Highly Cited
2008
Modulation of basal and stress‐induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L‐822429
N. Singewald
,
G. Chicchi
,
+7 authors
K. Ebner
Journal of Neurochemistry
2008
Corpus ID: 205619605
It has been shown that anxiety and stress responses are modulated by substance P (SP) released within the amygdala. However…
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