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L 822429

Known as: L-822429, L822429 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Alcohol dependence potentiates substance P/neurokinin-1 receptor signaling in the rat central nucleus of amygdala
Alcohol dependence induces hypersensitivity of the SP/NK-1R system and its regulation of CeA inhibitory transmission. Behavioral… 
2018
2018
The neurokinin-1 receptor mediates escalated alcohol intake induced by multiple drinking models
2015
2015
Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking
2015
2015
Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats
Substance P and its preferred neurokinin receptor NK1 have been implicated in stress and anxiety and have been proposed as… 
2014
2014
The Role of the Neurokinin-1 Receptor in Stress-Induced Reinstatement of Alcohol and Cocaine Seeking
Neurokinin-1 receptors (NK1Rs) have been shown to mediate alcohol and opiate, but not cocaine reward in rodents. We recently… 
2013
2013
The NK1 Receptor Antagonist L822429 Reduces Heroin Reinforcement
Genetic deletion of the neurokinin 1 receptor (NK1R) has been shown to decrease the reinforcing properties of opioids, but it is… 
2013
2013
Tacr1 Gene Variation and Neurokinin 1 Receptor Expression Is Associated with Antagonist Efficacy in Genetically Selected Alcohol-Preferring Rats
Highly Cited
2011
Highly Cited
2011
Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429
RationaleGenetic inactivation or pharmacological antagonism of neurokinin 1 (NK1) receptors blocks morphine and alcohol reward in… 
2011
2011
A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment
Increasing evidence suggests that specific physiological measures may serve as biomarkers for successful treatment to alleviate… 
Highly Cited
2008
Highly Cited
2008
Modulation of basal and stress‐induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L‐822429
It has been shown that anxiety and stress responses are modulated by substance P (SP) released within the amygdala. However… 
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