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L 822429

Known as: L-822429, L822429 
 
National Institutes of Health

Papers overview

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2018
2018
Cellular and behavioral effects of lipopolysaccharide treatment are dependent upon neurokinin-1 receptor activation
BackgroundSeveral psychiatric conditions are affected by neuroinflammation and neuroimmune activation. The transcription factor… Expand
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2015
2015
Neurokinin-1 receptor antagonism attenuates neuronal activity triggered by stress-induced reinstatement of alcohol seeking
Substance P (SP) and its cognate neurokinin-1 receptor (NK1R) are involved in alcohol-related behaviors. We have previously… Expand
2015
2015
Neurokinin 1 receptor blockade in the medial amygdala attenuates alcohol drinking in rats with innate anxiety but not in Wistar rats
Substance P and its preferred neurokinin receptor NK1 have been implicated in stress and anxiety and have been proposed as… Expand
2014
2014
The Role of the Neurokinin-1 Receptor in Stress-Induced Reinstatement of Alcohol and Cocaine Seeking
Neurokinin-1 receptors (NK1Rs) have been shown to mediate alcohol and opiate, but not cocaine reward in rodents. We recently… Expand
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2014
2014
Wistar rats acquire and maintain self-administration of 20 % ethanol without water deprivation, saccharin/sucrose fading, or extended access training
RationaleOperant self-administration (SA) is an important model of motivation to consume ethanol (EtOH), but low rates of… Expand
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2013
2013
The NK1 Receptor Antagonist L822429 Reduces Heroin Reinforcement
Genetic deletion of the neurokinin 1 receptor (NK1R) has been shown to decrease the reinforcing properties of opioids, but it is… Expand
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2013
2013
Tacr1 Gene Variation and Neurokinin 1 Receptor Expression Is Associated with Antagonist Efficacy in Genetically Selected Alcohol-Preferring Rats
BACKGROUND Genetic deletion or antagonism of the neurokinin 1 receptor (NK1R) decreases alcohol intake, alcohol reward, and… Expand
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Highly Cited
2011
Highly Cited
2011
Stress-induced reinstatement of alcohol-seeking in rats is selectively suppressed by the neurokinin 1 (NK1) antagonist L822429
RationaleGenetic inactivation or pharmacological antagonism of neurokinin 1 (NK1) receptors blocks morphine and alcohol reward in… Expand
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2011
2011
A mouse model of high trait anxiety shows reduced heart rate variability that can be reversed by anxiolytic drug treatment
Increasing evidence suggests that specific physiological measures may serve as biomarkers for successful treatment to alleviate… Expand
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Highly Cited
2008
Highly Cited
2008
Modulation of basal and stress‐induced amygdaloid substance P release by the potent and selective NK1 receptor antagonist L‐822429
It has been shown that anxiety and stress responses are modulated by substance P (SP) released within the amygdala. However… Expand
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