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L 767679

Known as: L 767,679, L-767,679, L-767679 
National Institutes of Health

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3 relations

Broader (2)

Piperazinesbeta-Alanine
analogs & derivatives

Papers overview

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1999
1999
Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa
Most clinical trials with fibrinogen receptor antagonists (FRAs) have been associated with thrombocytopenia. This report… 
1999
1999
Fibrinogen receptor antagonist-induced thrombocytopenia in chimpanzee and rhesus monkey associated with preexisting drug-dependent antibodies to platelet glycoprotein IIb/IIIa.
Most clinical trials with fibrinogen receptor antagonists (FRAs) have been associated with thrombocytopenia. This report… 
1998
1998
In vitro and in vivo evaluations of intestinal barriers for the zwitterion L-767,679 and its carboxyl ester prodrug L-775,318. Roles of efflux and metabolism.
The barriers to oral delivery of the hydrophilic zwitterion L-767, 679 (I) and its carboxyl ester prodrug L-775,318 (II) were… 
1997
1997
In vitro and in vivo evaluations of the metabolism, pharmacokinetics, and bioavailability of ester prodrugs of L-767,679, a potent fibrinogen receptor antagonist: an approach for the selection of a…
The present study demonstrates the utility of an in vitro-in vivo correlative approach in the selection of an optimum prodrug… 
1997
1997
Analysis of metabolite kinetics by deconvolution and in vivo-in vitro correlations of metabolite formation rates: studies of fibrinogen receptor antagonist ester prodrugs.
The pharmacokinetics of L-767,679, a potent fibrinogen receptor antagonist, were characterized following administration of its… 
1996
1996
Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.
The structure-activity relationship of a series of orally active glycoprotein IIb/IIIa antagonists containing a nitrogen… 
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