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L-4-chlorokynurenine

Known as: 4-Cl-KYN, AV-101, L-4-C1-KYN 
An orally bioavailable, blood brain barrier (BBB) penetrating, chlorinated analog of the endogenous neuromodulator kynurenic acid and prodrug of 7… Expand
National Institutes of Health

Papers overview

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Review
2018
Review
2018
Learning objective After participating in this activity, learners should be better able to evaluate the evidence supporting the… Expand
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Review
2017
Review
2017
ABSTRACT Introduction: The authors describe the medications for treatment-resistant depression (TRD) in phase II/III of clinical… Expand
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Highly Cited
2015
Highly Cited
2015
Currently approved antidepressant drug treatment typically takes several weeks to be effective. The noncompetitive N-methyl-d… Expand
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2010
2010
Kynurenic acid (KYNA) is an endogenous metabolite of tryptophan. Studies have revealed increased brain KYNA levels in patients… Expand
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Review
2009
Review
2009
Parkinson’s, Alzheimer’s and Huntington’s diseases are chronic neurodegenerative disorders of a progressive nature which lead to… Expand
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2007
2007
Kynurenic acid (KYNA) is an endogenous NMDA receptor antagonist as well as a blocker of the alpha7* nicotinic receptor and… Expand
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Highly Cited
2003
Highly Cited
2003
Summary. In the rodent brain, astrocytes are known to be the primary source of kynurenate (KYNA), an endogenous antagonist of… Expand
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2002
2002
Blockade of the strychnine-insensitive glycine site of the NMDA receptor is considered an attractive strategy for the development… Expand
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1996
1996
7-CHLOROKYNURENIC acid (7-Cl-KYNA) and 5,7-dichlorokynurenic acid (5,7-Cl2-KYNA) are of therapeutic interest as potent glycine/N… Expand
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1995
1995
The foliage of 62 specimens of Amaranthus belonging to 10 species of grain and four of vegetable type were analysed for vitamin C… Expand
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