L-4-chlorokynurenine

Known as: 4-Cl-KYN, AV-101, L-4-C1-KYN 
An orally bioavailable, blood brain barrier (BBB) penetrating, chlorinated analog of the endogenous neuromodulator kynurenic acid and prodrug of 7… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1992-2017
012319922017

Papers overview

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2015
2015
Currently approved antidepressant drug treatment typically takes several weeks to be effective. The noncompetitive N-methyl-d… (More)
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2014
2014
Changes in brain reward systems are thought to contribute significantly to the cognitive and behavioral impairments of… (More)
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2013
2013
Migraine is sexually dimorphic and associated in 20-30% of patients with an aura most likely caused by cortical spreading… (More)
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2012
2012
BACKGROUND The aura symptoms in migraine are most likely due to cortical spreading depression (CSD). CSD is favored by NMDA… (More)
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2012
2012
The glia-derived molecule kynurenic acid (KYNA) is an antagonist of α7 nicotinic acetylcholine receptors and the glycine(B… (More)
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Highly Cited
2010
Highly Cited
2010
Although an immunoregulatory role of aryl hydrocarbon receptor (Ahr) has been demonstrated in T cells and macrophages, little is… (More)
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2007
2007
Kynurenic acid (KYNA) is an endogenous NMDA receptor antagonist as well as a blocker of the alpha7* nicotinic receptor and… (More)
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2002
2002
Blockade of the strychnine-insensitive glycine site of the NMDA receptor is considered an attractive strategy for the development… (More)
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1996
1996
7-Chlorokynurenic acid (7-Cl-KYNA) and 5,7-dichlorokynurenic acid (5,7-Cl2-KYNA) are of therapeutic interest as potent glycine/N… (More)
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