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Knock-in
Replacement of a gene by an altered version of the same gene using homologous recombination resulting in a gain of function. One example of a knock…
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2016
2016
hort communication ltered GABAA receptor expression in brainstem nuclei and SUDEP in abrg 2 + / Q 390 X mice associated with epileptic encephalopathy
S. Pourali
,
T. Warnera
,
Chun-Qing Zhanga
,
obert L. Macdonalda
,
J. Kanga
2016
Corpus ID: 207725285
Sudden unexpected death in epilepsy (SUDEP) is the leading cause for death in individuals with epilepsy. The frequency of SUDEP…
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2012
2012
Overexpression of FoxO 1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance
Hye-Jin Kim
,
Masaki Kobayashi
,
+9 authors
T. Kitamura
2012
Corpus ID: 3998183
Metabolic Signal Research Center (H.-J.K., M.K., T.S., O.K., K.A., T.Kitaz., Y.-S.L., H.Y.-H., V.Y.S., Y.I.K., T.Kitam…
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2012
2012
Abstract 4410: Neutralizing Endosialin antibody, MORAb-004, enhances efficacy of TAXOTERE in a metastatic melanoma model
C. Krauthauser
,
L. Grasso
,
N. Nicolaides
,
Jianmin Lin
2012
Corpus ID: 71395738
Proceedings: AACR 103rd Annual Meeting 2012‐‐ Mar 31‐Apr 4, 2012; Chicago, IL Endosialin/Tumor Endothelial Marker-1 (TEM1) is a…
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2011
2011
Glycogen synthase kinase 3ß modulation in axonal regeneration
Helena I Pimentel
2011
Corpus ID: 55805114
The adult mammalian spinal cord fails to regenerate, contrarily to the injured peripheral nerve. In order to shed light on the…
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2011
2011
17 Chemokine receptors as therapeutic targets in atherosclerosis: pharmacological characterisation of the human CCR5 knock-in mouse
J. Maguire
,
P. Richards
,
R. Kuc
,
A. Davenport
Heart
2011
Corpus ID: 72861626
The CCR5 receptor and its ligands CCL3, CCL4 and CCL5 contribute to the initiation and progression of atherosclerosis. We have…
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2011
2011
The Roles of Conserved and Non-14 Conserved Cysteinyl Residues in the 15 Oligomerization and Function of 16 Mammalian Prestin
Benjamin Currall
,
Danielle Rossino
,
H. Jensen-Smith
,
R. Hallworth
2011
Corpus ID: 15934449
41 The creation of several prestin knock-out and knock-in mouse lines has demonstrated the 42 importance of the intrinsic outer…
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2011
2011
BEHAVIORAL DIFFERENCES IN A MOUSE MODEL OF BATTEN DISEASE
Jeffery T. Erickson
,
W. Klug
2011
Corpus ID: 17297472
Juvenile neuronal ceroid lipofuscinosis (JNCL), or Batten disease, is an autosomal recessive human neurodegenerative disease…
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2010
2010
Longitudinal study of neurochemical changes in Q 140 mouse model of Huntington ’ s disease
I. Tkáč
,
L. Zacharoff
,
J. Dubinsky
2010
Corpus ID: 46935956
INTRODUCTION The Q140 knock-in mouse model of Hutingtin’s disease (HD) may be a more meaningful model of pathology in human…
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2008
2008
Kei on GSK: a contribution by the 2007 recipient of the Young Scientist Award.
A. Klip
American Journal of Physiology. Endocrinology and…
2008
Corpus ID: 13141235
from time to time, we like to highlight articles authored by winners of the awards offered by the American Physiological Society…
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1998
1998
Na,K-ATPase Subunit b1 knock-in Prevents Lethality of b2 Deficiency in Mice
U. Bartsch
,
M. Schachner
,
D. Montag
1998
Corpus ID: 15143589
The b2 subunit of the Na,K-ATPase displays functional properties of both an integral constituent of an ion pump and an adhesion…
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