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Kit Ligand, human

Known as: C-Kit Ligand, Steel Factor, MGF Stem Cell Factor 
A substance that causes blood stem cells (cells from which other types of cells develop) to change into different types of blood cells and increases… 
National Institutes of Health

Related topics

Related topics

20 relations
Bone MarrowCytokine GeneCytokine Receptor BindingCytokine Signaling

Broader (1)

Stem Cell Factor

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Differential cytokine contributions of perivascular haematopoietic stem cell niches
Arterioles and sinusoids of the bone marrow (BM) are accompanied by stromal cells that express nerve/glial antigen 2 (NG2) and… 
Highly Cited
2006
Highly Cited
2006
Osteoclasts degrade endosteal components and promote mobilization of hematopoietic progenitor cells
Here we investigated the potential role of bone-resorbing osteoclasts in homeostasis and stress-induced mobilization of… 
Highly Cited
1999
Highly Cited
1999
Myofibroblasts. II. Intestinal subepithelial myofibroblasts.
Intestinal subepithelial myofibroblasts (ISEMF) and the interstitial cells of Cajal are the two types of myofibroblasts… 
Highly Cited
1998
Highly Cited
1998
Gain-of-function mutations of c-kit in human gastrointestinal stromal tumors.
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal tumors in the human digestive tract, but their molecular… 
Highly Cited
1994
Highly Cited
1994
Identification of a common T/natural killer cell progenitor in human fetal thymus
The phenotypic similarities between natural killer (NK) and T cells have led to the hypothesis that these distinctive lymphocyte… 
Highly Cited
1993
Highly Cited
1993
Identification of mutations in the coding sequence of the proto-oncogene c-kit in a human mast cell leukemia cell line causing ligand-independent activation of c-kit product.
The c-kit proto-oncogene encodes a receptor tyrosine kinase. Binding of c-kit ligand, stem cell factor (SCF) to c-kit receptor (c… 
Highly Cited
1992
Highly Cited
1992
In vivo and in vitro stem cell function of c-kit- and Sca-1-positive murine hematopoietic cells.
c-kit is expressed on hematopoietic stem cells and progenitor cells, but not on lymphohematopoietic differentiated cells. Lineage… 
Highly Cited
1991
Highly Cited
1991
Effects of the steel gene product on mouse primordial germ cells in culture
MUTATIONS at the steel (si) and dominant white spotting (W) loci in the mouse affect primordial germ cells (PGC), melanoblasts… 
Highly Cited
1990
Highly Cited
1990
Stem cell factor is encoded at the SI locus of the mouse and is the ligand for the c-kit tyrosine kinase receptor
Highly Cited
1990
Highly Cited
1990
Identification of a ligand for the c-kit proto-oncogene
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