Kinesin-1 Heavy Chain

Known as: Conventional Kinesin Heavy Chain, Kinesin Heavy Chain, Ubiquitous Kinesin Heavy Chain 
Kinesin-1 heavy chain (963 aa, ~110 kDa) is encoded by the human KIF5B gene. This protein is involved in organelle and vesicle transport.
National Institutes of Health

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Cellular MembraneIntracellular TransportKIF5B geneLigand Binding
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Papers overview

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2016
2016
Microtubule-microtubule sliding by kinesin-1 is essential for normal cytoplasmic streaming in Drosophila oocytes.
Cytoplasmic streaming in Drosophila oocytes is a microtubule-based bulk cytoplasmic movement. Streaming efficiently circulates… (More)
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2016
2016
Role of kinesin-1-based microtubule sliding in Drosophila nervous system development.
The plus-end microtubule (MT) motor kinesin-1 is essential for normal development, with key roles in the nervous system. Kinesin… (More)
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Highly Cited
2010
Highly Cited
2010
Kinesin-1 heavy chain mediates microtubule sliding to drive changes in cell shape.
Microtubules are typically observed to buckle and loop during interphase in cultured cells by an unknown mechanism. We show that… (More)
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2010
2010
Role of kinesin light chain-2 of kinesin-1 in the traffic of Na,K-ATPase-containing vesicles in alveolar epithelial cells.
Recruitment of the Na,K-ATPase to the plasma membrane of alveolar epithelial cells results in increased active Na(+) transport… (More)
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2009
2009
The Processivity of Kinesin-2 Motors Suggests Diminished Front-Head Gating
Kinesin-2 motors, which are involved in intraflagellar transport and cargo transport along cytoplasmic microtubules, differ from… (More)
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2008
2008
Kinesin-1 (uKHC/KIF5B) is required for bidirectional motility of ER exit sites and efficient ER-to-Golgi transport.
Transport of proteins and lipids between intracellular compartments is fundamental to the organization and function of eukaryotic… (More)
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Highly Cited
2006
Highly Cited
2006
Cargo selection by specific kinesin light chain 1 isoforms.
Kinesin-1 drives the movement of diverse cargoes, and it has been proposed that specific kinesin light chain (KLC) isoforms… (More)
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Highly Cited
2002
Highly Cited
2002
Herpes simplex virus tegument protein US11 interacts with conventional kinesin heavy chain.
Little is known about the mechanisms of transport of neurotropic herpesviruses, such as herpes simplex virus (HSV), varicella… (More)
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2002
2002
The heavy chain of conventional kinesin interacts with the SNARE proteins SNAP25 and SNAP23.
Recent studies on the conventional motor protein kinesin have identified a putative cargo-binding domain (residues 827-906… (More)
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2000
2000
Expression and partial characterization of kinesin-related proteins in differentiating and adult skeletal muscle.
Using pan-kinesin antibodies to screen a differentiating C2C12 cell library, we identified the kinesin proteins KIF3A, KIF3B, and… (More)
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