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KW 6002

Known as: KW-6002 
 
National Institutes of Health

Papers overview

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Highly Cited
2010
Highly Cited
2010
The objectives of this study were to evaluate the efficacy of istradefylline at an oral dose of 20 mg or 40 mg once daily for 12… Expand
Highly Cited
2008
Highly Cited
2008
Based on new understanding of nondopaminergic pathways involved in Parkinson's disease (PD) pathophysiology, a selective… Expand
Highly Cited
2008
Highly Cited
2008
To investigate whether the motor and neuroprotective effects of adenosine A2A receptor (A2AR) antagonists are mediated by… Expand
Highly Cited
2007
Highly Cited
2007
This study assessed whether dopamine in the dorsomedial striatum is necessary for flexible adaptation to changes in stimulus… Expand
Highly Cited
2003
Highly Cited
2003
We have examined the ability of KW‐6002, an adenosine A2a antagonist, to modulate the dyskinetic effects of l‐DOPA in 6… Expand
Highly Cited
2003
Highly Cited
2003
Background: Observations in animal models suggest that A2A antagonists confer benefit by modulating dopaminergic effects on the… Expand
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Highly Cited
2000
Highly Cited
2000
The novel selective adenosine A(2A) receptor antagonist KW-6002 improves motor disability in MPTP-treated parkinsonian marmosets… Expand
Highly Cited
2000
Highly Cited
2000
The effects of novel adenosine A(2A) receptor antagonists KF17837 ((E)-1,3-dipropyl-8-(3,4-dimethoxystyryl)-7-methyl-3, 7-dihydro… Expand
Highly Cited
1999
Highly Cited
1999
Abstract Rationale: Current treatment of Parkinson’s disease (PD) is based on dopamine replacement therapy, but this leads to… Expand
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Highly Cited
1998
Highly Cited
1998
Treatment of Parkinson's disease with L‐dopa therapy leads to long‐term complications, including loss of drug efficacy and the… Expand