KW-2450

Known as: IGF-1R/IR Inhibitor KW-2450 
An orally bioavailable inhibitor of insulin-like growth factor 1 receptor (IGF-1R) and insulin receptor (IR) tyrosine kinases with potential… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

2003-2015
0120032015

Papers overview

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2016
2016
Numerous solid tumors overexpress or have excessively activated insulin-like growth factor receptor-1 (IGF-1R). We summarize… (More)
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2016
2016
OBJECTIVE We explored the role of insulin-like growth factor 1 (igf-1) in the development of lung cancer. METHODS We used… (More)
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2015
2015
Currently, no targeted drug is available for triple-negative breast cancer (TNBC), an aggressive breast cancer that does not… (More)
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2011
2011
3078 Background: KW-2450, a potent small molecule insulin-like growth factor receptor (IGF-1R)/insulin receptor (IR) antagonist… (More)
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2010
2010
ownload lin-like growth factor-1 receptor (IGF-1R) is a receptor tyrosine kinase (RTK) and critical activator of… (More)
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2006
2006
The type 1 insulin-like growth factor receptor (IGF-1R) has been extensively reported to play an important role in cancer… (More)
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2003
2003
PURPOSE Insulin-like growth factor (IGF)-1 and its receptor (IGF-1R) are associated with abnormal retinal neovascularization… (More)
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