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KU 60019
Known as:
KU-60019
, KU60019
National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Review
2019
Review
2019
ATM in DNA repair in cancer.
M. Jin
,
D. Oh
Pharmacology and Therapeutics
2019
Corpus ID: 196350000
2019
2019
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy
Juan Zhao
,
Lam N. Nguyen
,
+15 authors
Z. Yao
Frontiers in Immunology
2019
Corpus ID: 207759401
HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in…
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2018
2018
ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion
Lei Lang
,
Yixuan Hou
,
+11 authors
Manran Liu
Cellular Physiology and Biochemistry
2018
Corpus ID: 56477598
Background/Aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and…
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Highly Cited
2017
Highly Cited
2017
Chemical screening identifies ATM as a target for alleviating senescence.
H. T. Kang
,
Joon-Tae Park
,
+5 authors
S. Park
Nature Chemical Biology
2017
Corpus ID: 1635314
Senescence, defined as irreversible cell-cycle arrest, is the main driving force of aging and age-related diseases. Here, we…
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2015
2015
Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019
D. Vecchio
,
A. Daga
,
+13 authors
G. Fròsina
International Journal of Cancer
2015
Corpus ID: 27875317
We have recently reported that glioblastoma (GB)‐initiating cells (GIC) with low expression and/or mutation of TP53 and high…
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2015
2015
Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.
Masaki Nagane
,
Hironobu Yasui
,
+5 authors
O. Inanami
Biochemical and Biophysical Research…
2015
Corpus ID: 7741551
Highly Cited
2014
Highly Cited
2014
Predictability, efficacy and safety of radiosensitization of glioblastoma‐initiating cells by the ATM inhibitor KU‐60019
D. Vecchio
,
A. Daga
,
+12 authors
G. Fròsina
International Journal of Cancer
2014
Corpus ID: 25572673
We have previously shown that pharmacological inhibition of ataxia telangiectasia mutated (ATM) protein sensitizes glioblastoma…
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Highly Cited
2013
Highly Cited
2013
ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation
Laura Biddlestone-Thorpe
,
Muhammad Sajjad
,
+17 authors
K. Valerie
Clinical Cancer Research
2013
Corpus ID: 12110572
Purpose: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer with a median survival of only 12 to 15 months…
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Highly Cited
2012
Highly Cited
2012
Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control
Sarah E. Golding
,
E. Rosenberg
,
+4 authors
K. Valerie
Cell Cycle
2012
Corpus ID: 22516278
Glioblastoma multiforme (GBM) is notoriously resistant to treatment. Therefore, new treatment strategies are urgently needed. ATM…
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Highly Cited
2009
Highly Cited
2009
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Sarah E. Golding
,
E. Rosenberg
,
+11 authors
K. Valerie
Molecular Cancer Therapeutics
2009
Corpus ID: 2396941
Ataxia telangiectasia (A-T) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule…
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