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KU 60019

Known as: KU-60019, KU60019 
National Institutes of Health

Papers overview

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Review
2019
Review
2019
ATM in DNA repair in cancer.
  • M. JinD. Oh
  • Pharmacology and Therapeutics
  • 2019
  • Corpus ID: 196350000
2019
2019
ATM Deficiency Accelerates DNA Damage, Telomere Erosion, and Premature T Cell Aging in HIV-Infected Individuals on Antiretroviral Therapy
HIV infection leads to a phenomenon of inflammaging, in which chronic inflammation induces an immune aged phenotype, even in… 
2018
2018
ATM-Mediated Phosphorylation of Cortactin Involved in Actin Polymerization Promotes Breast Cancer Cells Migration and Invasion
Background/Aims: The ataxia-telangiectasia mutated (ATM) protein kinase is critical for the maintenance of genomic stability and… 
Highly Cited
2017
Highly Cited
2017
Chemical screening identifies ATM as a target for alleviating senescence.
Senescence, defined as irreversible cell-cycle arrest, is the main driving force of aging and age-related diseases. Here, we… 
2015
2015
Pharmacokinetics, pharmacodynamics and efficacy on pediatric tumors of the glioma radiosensitizer KU60019
We have recently reported that glioblastoma (GB)‐initiating cells (GIC) with low expression and/or mutation of TP53 and high… 
2015
2015
Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway.
Highly Cited
2014
Highly Cited
2014
Predictability, efficacy and safety of radiosensitization of glioblastoma‐initiating cells by the ATM inhibitor KU‐60019
We have previously shown that pharmacological inhibition of ataxia telangiectasia mutated (ATM) protein sensitizes glioblastoma… 
Highly Cited
2013
Highly Cited
2013
ATM Kinase Inhibition Preferentially Sensitizes p53-Mutant Glioma to Ionizing Radiation
Purpose: Glioblastoma multiforme (GBM) is the most lethal form of brain cancer with a median survival of only 12 to 15 months… 
Highly Cited
2012
Highly Cited
2012
Dynamic inhibition of ATM kinase provides a strategy for glioblastoma multiforme radiosensitization and growth control
Glioblastoma multiforme (GBM) is notoriously resistant to treatment. Therefore, new treatment strategies are urgently needed. ATM… 
Highly Cited
2009
Highly Cited
2009
Improved ATM kinase inhibitor KU-60019 radiosensitizes glioma cells, compromises insulin, AKT and ERK prosurvival signaling, and inhibits migration and invasion
Ataxia telangiectasia (A-T) mutated (ATM) is critical for cell cycle checkpoints and DNA repair. Thus, specific small molecule… 
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