KT 6528

Known as: 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1,3(2H)-dione, 9,10,11,12-tetrahydro-2,10-dihydroxy-10-(hydroxymethyl)-9-methyl-, (9S-(9alpha,10beta,12alpha))-, KT-6528, KT6528

National Institutes of Health

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1992

Induction of mammalian DNA topoisomerase I mediated DNA cleavage by antitumor indolocarbazole derivatives.

Yoshinori Yamashita, Norie Fujii, Chikara Murakata, Tadashi Ashizawa, Mayuko Okabe, Hideko Nakano
Biochemistry
1992

DNA topoisomerases have been shown to be important therapeutic targets in cancer chemotherapy. We found that KT6006 and KT6528… (More)

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KT 6528

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