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KRN 7000

Known as: KRN-7000, KRN7000 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Antineoplastic AgentsGalactosylceramidesImmunologic Adjuvants
alpha-galactosylceramide

Papers overview

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2010
2010
Syntheses and biological activities of KRN7000 analogues having aromatic residues in the acyl and backbone chains with varying stereochemistry.
2008
2008
RCAI-8, 9, 18, 19, and 49-52, conformationally restricted analogues of KRN7000 with an azetidine or a pyrrolidine ring: Their synthesis and bioactivity for mouse natural killer T cells to produce…
2008
2008
Synthesis of alpha-galactosyl ceramide (KRN7000) and analogues thereof via a common precursor and their preliminary biological assessment.
A new practical synthesis of alpha-GalCer and of its analogues is presented, opening the chance to easily modify the sphingosine… 
2008
2008
RCAI-17, 22, 24-26, 29, 31, 34-36, 38-40, and 88, the analogs of KRN7000 with a sulfonamide linkage: their synthesis and bioactivity for mouse natural killer T cells to produce Th2-biased cytokines.
2000
2000
Functional natural killer T cells in experimental mouse strains, including NK1.1- strains.
Natural killer T (NKT) cells are a newly discovered subset of lymphocytes. It appears that this subset has potential as important… 
1999
1999
Synthesis of NBD-alpha-galactosylceramide and its immunologic properties.
[formula: see text] A representative alpha-galactosylceramide (alpha-GalCer), KRN7000, can activate NKT cells through CD1d… 
Highly Cited
1999
Highly Cited
1999
Syntheses of biotinylated alpha-galactosylceramides and their effects on the immune system and CD1 molecules.
A representative alpha-galactosylceramide (alpha-GalCer), KRN7000, has strong immunostimulatory and antitumor activity. Recent… 
1999
1999
Effects of α‐galactosylceramide (KRN7000), interleukin‐12 and interleukin‐7 on phenotype and cytokine profile of human Vα24+ Vβ11+ T cells
The α‐galactosylceramide KRN7000 was reported to be presented by CD1d to natural killer (NK) T cells, cells that are thought to… 
Highly Cited
1998
Highly Cited
1998
Antitumor activity of alpha-galactosylceramide, KRN7000, in mice with EL-4 hepatic metastasis and its cytokine production.
Liver metastasis of primary tumor is a clinically major problem. KRN7000, an alpha-galactosylceramide, significantly augments… 
Review
1997
Review
1997
[Development of KRN7000, derived from agelasphin produced by Okinawan sponge].
New glycosphingolipids, named agelasphins, have been isolated as antitumoral compounds from an extract of a marine sponge, Agelas… 
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