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KRAS NP_004976.2:p.G12D
Known as:
KRAS p.G12D
, KRAS G12D
, KRAS NP_004976.2:p.Gly12Asp
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A change in the amino acid residue at position 12 in the GTPase KRas protein where glycine has been replaced by aspartic acid.
National Institutes of Health
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Related topics
Related topics
1 relation
Kras gene mutation
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
[Mouse models for human colorectal cancer with liver metastasis].
X. Huang
,
Y. B. Zheng
,
Y. J. Yang
,
C. Yang
,
H. Li
,
H. Cheng
Zhonghua yi xue za zhi
2019
Corpus ID: 202557115
Objective: To established Apc(loxp/loxp)+Kras(LSL-G12D/-)+Smad4(loxp/loxp) transgenic mouse model that mimick the occurrence and…
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2019
2019
Abstract B25: Engrailed-1 promotes pancreatic cancer progression via antagonizing COMPASS activity
C. Hwang
,
Jae-seok Roe
,
+8 authors
D. Tuveson
2019
Corpus ID: 213948264
Pancreatic ductal adenocarcinoma (PDA) is the most deadly disease in human malignancies. Using pancreatic organoid models, we…
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2017
2017
Abstract 1391: The epigenetic regulator, G9a, is a KRAS-inducible protein and its inactivation inhibits PanIN formation by this oncogene
Angela J. Mathison
,
Ann Salmonson
,
+5 authors
G. Lomberk
2017
Corpus ID: 79768139
Pancreatic ductular adenocarcinoma (PDAC) ranks fourth as a cause of cancer death in the USA and is almost universally fatal…
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2015
2015
Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice
Jan P. Böttcher
,
S. Zelenay
,
N. Rogers
,
J. Helft
,
Barbara U. Schraml
,
C. Reis e Sousa
Journal of Immunology
2015
Corpus ID: 15783984
Dendritic cells (DCs) are powerful APCs that can induce Ag-specific adaptive immune responses and are increasingly recognized as…
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2013
2013
Hexokinase 2 required in tumors
P. Feliciano
Nature Genetics
2013
Corpus ID: 42288747
or mice carrying activated ErbB2 (Neu), a model of breast cancer, to Hk2 conditional knockout mice. They found that the average…
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2013
2013
Mutation signature of aristolochic acid
E. Niemitz
Nature Genetics
2013
Corpus ID: 20490624
weight matrix models for binding affini-ties based on analysis of data from chromatin immunoprecipitation and sequencing (ChIP…
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2013
2013
Abstract 2070: Natural vitamin E delta-tocotrienol combined with gemcitabine prolongs the survival, induces apoptosis, inhibits tumor growth, angiogenesis and oncogenic signaling in a transgenic…
K. Husain
,
B. Centeno
,
Marta Pérez
,
Chen Dung-Tsa
,
S. Sebti
,
M. Malafa
2013
Corpus ID: 72754927
Background: Pancreatic cancer, an aggressive and lethal cancer is the fourth leading cause of cancer-related deaths in the United…
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2012
2012
Cancer Initiation and Progression in a Therapeutically Resistant Kras and p 53-Induced Mouse Model of Lung Adenocarcinoma
A. Kasinski
,
F. Slack
2012
Corpus ID: 26557139
Lung cancer is the leading cause of cancer deaths worldwide, and current therapies fail to treat this disease in the vast…
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2012
2012
Abstract A5: Imaging heterogeneity of endogenous mouse models of pancreatic cancer.
I. Heid
,
M. Trajkovic-Arsic
,
+7 authors
R. Braren
2012
Corpus ID: 71884598
Human pancreatic ductal adenocarcinoma (PDAC) displays high heterogeneity in terms of morphology, onset, and therapy response…
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2012
2012
Model of Lung Adenocarcinoma Therapeutically Resistant K-ras and p53-Induced Mouse miRNA-34 Prevents Cancer Initiation and Progression in a
A. Kasinski
,
F. Slack
2012
Corpus ID: 18009882
Lung cancer is the leading cause of cancer deaths worldwide, and current therapies fail to treat this disease in the vast…
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