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KRAS NP_004976.2:p.G12D

Known as: KRAS p.G12D, KRAS G12D, KRAS NP_004976.2:p.Gly12Asp 
A change in the amino acid residue at position 12 in the GTPase KRas protein where glycine has been replaced by aspartic acid.
National Institutes of Health

Related topics

Related topics

1 relation
Kras gene mutation

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
[Mouse models for human colorectal cancer with liver metastasis].
Objective: To established Apc(loxp/loxp)+Kras(LSL-G12D/-)+Smad4(loxp/loxp) transgenic mouse model that mimick the occurrence and… 
2019
2019
Abstract B25: Engrailed-1 promotes pancreatic cancer progression via antagonizing COMPASS activity
Pancreatic ductal adenocarcinoma (PDA) is the most deadly disease in human malignancies. Using pancreatic organoid models, we… 
2017
2017
Abstract 1391: The epigenetic regulator, G9a, is a KRAS-inducible protein and its inactivation inhibits PanIN formation by this oncogene
Pancreatic ductular adenocarcinoma (PDAC) ranks fourth as a cause of cancer death in the USA and is almost universally fatal… 
2015
2015
Oncogenic Transformation of Dendritic Cells and Their Precursors Leads to Rapid Cancer Development in Mice
Dendritic cells (DCs) are powerful APCs that can induce Ag-specific adaptive immune responses and are increasingly recognized as… 
2013
2013
Hexokinase 2 required in tumors
or mice carrying activated ErbB2 (Neu), a model of breast cancer, to Hk2 conditional knockout mice. They found that the average… 
2013
2013
Mutation signature of aristolochic acid
weight matrix models for binding affini-ties based on analysis of data from chromatin immunoprecipitation and sequencing (ChIP… 
2013
2013
Abstract 2070: Natural vitamin E delta-tocotrienol combined with gemcitabine prolongs the survival, induces apoptosis, inhibits tumor growth, angiogenesis and oncogenic signaling in a transgenic…
Background: Pancreatic cancer, an aggressive and lethal cancer is the fourth leading cause of cancer-related deaths in the United… 
2012
2012
Cancer Initiation and Progression in a Therapeutically Resistant Kras and p 53-Induced Mouse Model of Lung Adenocarcinoma
Lung cancer is the leading cause of cancer deaths worldwide, and current therapies fail to treat this disease in the vast… 
2012
2012
Abstract A5: Imaging heterogeneity of endogenous mouse models of pancreatic cancer.
Human pancreatic ductal adenocarcinoma (PDAC) displays high heterogeneity in terms of morphology, onset, and therapy response… 
2012
2012
Model of Lung Adenocarcinoma Therapeutically Resistant K-ras and p53-Induced Mouse miRNA-34 Prevents Cancer Initiation and Progression in a
Lung cancer is the leading cause of cancer deaths worldwide, and current therapies fail to treat this disease in the vast… 
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