FAQ

KRAS NP_004976.2:p.G12D

Known as: KRAS p.G12D, KRAS G12D, KRAS NP_004976.2:p.Gly12Asp 
A change in the amino acid residue at position 12 in the GTPase KRas protein where glycine has been replaced by aspartic acid.

Topic mentions per year

Topic mentions per year

1999-2018
051019992018

Related topics

Related topics

3 relations
KRAS NM_004985.3:c.35G>AKRAS NM_004985.3:c.35_36delGTinsACKras gene mutation

Related mentions per year

Related mentions per year

1997-2018
1990200020102020
KRAS NP_004976.2:p.G12D
Kras gene mutation
KRAS NM_004985.3:c.35G>A
KRAS NM_004985.3:c.35_36delGTinsAC

Papers overview

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Highly Cited
2016
Highly Cited
2016
T-Cell Transfer Therapy Targeting Mutant KRAS in Cancer.
We identified a polyclonal CD8+ T-cell response against mutant KRAS G12D in tumor-infiltrating lymphocytes obtained from a… (More)
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2016
2016
KRAS G12D Mutation Subtype Is A Prognostic Factor for Advanced Pancreatic Adenocarcinoma
Objectives:There is no molecular biomarker available in the clinical practice to assess the prognosis of advanced pancreatic… (More)
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Highly Cited
2015
Highly Cited
2015
Single-cell mRNA sequencing identifies subclonal heterogeneity in anti-cancer drug responses of lung adenocarcinoma cells
Intra-tumoral genetic and functional heterogeneity correlates with cancer clinical prognoses. However, the mechanisms by which… (More)
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2013
2013
KRAS and BRAF Mutation Analysis in Colorectal Adenocarcinoma Specimens with a Low Percentage of Tumor Cells
The rapid development of molecular biology techniques allows for the introduction of real-time polymerase chain reaction (PCR… (More)
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2013
2013
Computational Analysis of KRAS Mutations: Implications for Different Effects on the KRAS p.G12D and p.G13D Mutations
BACKGROUND The issue of whether patients diagnosed with metastatic colorectal cancer who harbor KRAS codon 13 mutations could… (More)
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2013
2013
Notch1 gene mutations target KRAS G12D-expressing CD8+ cells and contribute to their leukemogenic transformation.
Acute T-cell lymphoblastic leukemia/lymphoma (T-ALL) is an aggressive hematopoietic malignancy affecting both children and adults… (More)
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2010
2010
Combined analysis of specific KRAS mutation, BRAF and microsatellite instability identifies prognostic subgroups of sporadic and hereditary colorectal cancer.
Confounding effects of specific KRAS gene alterations on colorectal cancer (CRC) prognosis stratified by microsatellite… (More)
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2010
2010
Patient with colorectal cancer with heterogeneous KRAS molecular status responding to cetuximab-based chemotherapy.
A 77-year-old man who had undergone resection of the descending colon, the sixth hepatic segment, and peritoneal biopsy… (More)
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2008
2008
Gene expression deregulation by KRAS G12D and G12V in a BRAF V600E context
KRAS and BRAF mutations appear of relevance in the genesis and progression of several solid tumor types but the co-occurrence and… (More)
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2007
2007
Radiohybridization PET imaging of KRAS G12D mRNA expression in human pancreas cancer xenografts with [(64)Cu]DO3A-peptide nucleic acid-peptide nanoparticles.
There is a compelling need to image pancreas cancer at an early stage. Human pancreas cancer cells display elevated levels of… (More)
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