KPU-300

National Institutes of Health

Papers overview

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2017

2017

Click strategy using disodium salts of amino acids improves the water solubility of plinabulin and KPU-300.

Fumika Yakushiji, Kyohei Muguruma, +7 authors Yoshio Hayashi
Bioorganic & medicinal chemistry
2017

Plinabulin and KPU-300 are promising anti-microtubule agents; however, the low water solubility of these compounds (<0.1µg/mL… (More)

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2015

2015

KPU-300, a Novel Benzophenone-Diketopiperazine-Type Anti-Microtubule Agent with a 2-Pyridyl Structure, Is a Potent Radiosensitizer That Synchronizes the Cell Cycle in Early M Phase.

Kohei Okuyama, Atsushi Kaida, Yoshiki Hayashi, Yoshio Hayashi, Kiyoshi Harada, Masahiko Miura
PloS one
2015

KPU-300 is a novel colchicine-type anti-microtubule agent derived from plinabulin (NPI-2358). We characterized the effects of KPU… (More)

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2014

2014

Development of a new benzophenone-diketopiperazine-type potent antimicrotubule agent possessing a 2-pyridine structure.

Yoshiki Hayashi, Haruka Takeno, +8 authors Yoshio Hayashi
ACS medicinal chemistry letters
2014

A new benzophenone-diketopiperazine-type potent antimicrotubule agent was developed by modifying the structure of the clinical… (More)

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