Skip to search formSkip to main content
You are currently offline. Some features of the site may not work correctly.

KN 62

Known as: 5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester, (S)-, KN-62, KN62 compound 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7… Expand
Is this relevant?
Highly Cited
2000
Highly Cited
2000
Long-term habituation to a novel environment is one of the most elementary forms of nonassociative learning. Here we studied the… Expand
  • figure 2
  • figure 1
  • figure 3
  • figure 4
Is this relevant?
Highly Cited
2000
Highly Cited
2000
In human and rodent macrophages, activation of the P2X7 nucleotide receptor stimulates interleukin-1beta processing and release… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of… Expand
Is this relevant?
Highly Cited
1997
Highly Cited
1997
1. Extracellular adenosine 5'-triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of… Expand
Is this relevant?
1995
1995
We have used monolayers of parental 3T3 fibroblasts and 3T3 cells expressing transfected cell adhesion molecules (CAMs, NCAM, N… Expand
Is this relevant?
1992
1992
To probe for the involvement of Ca2+/calmodulin-dependent protein kinase II in the regulation of insulin secretion, the effects… Expand
Is this relevant?
Highly Cited
1991
Highly Cited
1991
We reported that one of the isoquinolinesulfonamide derivatives, KN-62, is a potent and specific inhibitor of Ca2+/calmodulin… Expand
Is this relevant?
1991
1991
Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl- 4-phenylpiperazine), a specific inhibitor of calcium… Expand
Is this relevant?
Highly Cited
1990
Highly Cited
1990
1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpipera zine (KN-62), a selective inhibitor of rat brain Ca2… Expand
Is this relevant?