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KN 62

Known as: 5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester, (S)-, KN-62, KN62 compound 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Enzyme InhibitorsIsoquinolinesPiperazines
analogs & derivatives

Papers overview

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Highly Cited
2008
Highly Cited
2008
P2X7 receptor-Pannexin1 complex: pharmacology and signaling.
Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7… 
Highly Cited
2000
Highly Cited
2000
Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats
Highly Cited
1997
Highly Cited
1997
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation.
Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of… 
Highly Cited
1997
Highly Cited
1997
The isoquinoline derivative KN‐62 a potent antagonist of the P2Z‐receptor of human lymphocytes
Extracellular adenosine 5′‐triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of a… 
Highly Cited
1994
Highly Cited
1994
Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.
Highly Cited
1994
Highly Cited
1994
A role for protein kinases and phosphatases in the Ca2+-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses
Highly Cited
1992
Highly Cited
1992
Phosphorylation of myosin light chain kinase by the multifunctional calmodulin-dependent protein kinase II in smooth muscle cells.
Highly Cited
1992
Highly Cited
1992
Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type…
To probe for the involvement of Ca2+/calmodulin-dependent protein kinase II in the regulation of insulin secretion, the effects… 
Highly Cited
1991
Highly Cited
1991
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.
Highly Cited
1990
Highly Cited
1990
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
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