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KN 62

Known as: 5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester, (S)-, KN-62, KN62 compound 
National Institutes of Health

Related topics

Related topics

4 relations

Broader (3)

Enzyme InhibitorsIsoquinolinesPiperazines
analogs & derivatives

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
P2X7 receptor-Pannexin1 complex: pharmacology and signaling.
Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7… Expand
Highly Cited
2000
Highly Cited
2000
Role of hippocampal signaling pathways in long-term memory formation of a nonassociative learning task in the rat.
Long-term habituation to a novel environment is one of the most elementary forms of nonassociative learning. Here we studied the… Expand
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Highly Cited
1997
Highly Cited
1997
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation.
Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of… Expand
Highly Cited
1997
Highly Cited
1997
The isoquinoline derivative KN‐62 a potent antagonist of the P2Z‐receptor of human lymphocytes
Extracellular adenosine 5′‐triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of a… Expand
Highly Cited
1995
Highly Cited
1995
A Ca2+/Calmodulin Kinase Inhibitor, KN-62, Inhibits Neurite Outgrowth Stimulated by CAMs and FGF
We have used monolayers of parental 3T3 fibroblasts and 3T3 cells expressing transfected cell adhesion molecules (CAMs, NCAM, N… Expand
Highly Cited
1994
Highly Cited
1994
Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.
We have characterized Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV), expressed using the baculovirus/Sf9 cell… Expand
Highly Cited
1992
Highly Cited
1992
Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type…
To probe for the involvement of Ca2+/calmodulin-dependent protein kinase II in the regulation of insulin secretion, the effects… Expand
Highly Cited
1991
Highly Cited
1991
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.
We reported that one of the isoquinolinesulfonamide derivatives, KN-62, is a potent and specific inhibitor of Ca2+/calmodulin… Expand
Highly Cited
1991
Highly Cited
1991
Effects of KN-62, a specific inhibitor of calcium/calmodulin-dependent protein kinase II, on long-term potentiation in the rat hippocampus
Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl- 4-phenylpiperazine), a specific inhibitor of calcium… Expand
Highly Cited
1990
Highly Cited
1990
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpipera zine (KN-62), a selective inhibitor of rat brain Ca2… Expand
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