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KN 62
Known as:
5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester, (S)-
, KN-62
, KN62 compound
National Institutes of Health
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Related topics
Related topics
4 relations
Broader (3)
Enzyme Inhibitors
Isoquinolines
Piperazines
analogs & derivatives
Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2008
Highly Cited
2008
P2X7 receptor-Pannexin1 complex: pharmacology and signaling.
R. Iglesias
,
S. Locovei
,
+4 authors
E. Scemes
American journal of physiology. Cell physiology
2008
Corpus ID: 19361317
Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7…
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Highly Cited
2000
Highly Cited
2000
Inhibition of the amygdala and hippocampal calcium/calmodulin-dependent protein kinase II attenuates the dependence and relapse to morphine differently in rats
Lin Lu
,
Shaoshu Zeng
,
Dehong Liu
,
X. Ceng
Neuroscience Letters
2000
Corpus ID: 21927125
Highly Cited
1997
Highly Cited
1997
Regulatory phosphorylation of AMPA-type glutamate receptors by CaM-KII during long-term potentiation.
A. Barria
,
D. Muller
,
V. Derkach
,
Leslie C. Griffith
,
T. Soderling
Science
1997
Corpus ID: 24839103
Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of…
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Highly Cited
1997
Highly Cited
1997
The isoquinoline derivative KN‐62 a potent antagonist of the P2Z‐receptor of human lymphocytes
C. Gargett
,
J. Wiley
British journal of pharmacology
1997
Corpus ID: 6264488
Extracellular adenosine 5′‐triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of a…
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Highly Cited
1994
Highly Cited
1994
Characterization of Ca2+/calmodulin-dependent protein kinase IV. Role in transcriptional regulation.
H. Enslen
,
P. Sun
,
D. Brickey
,
S. Soderling
,
E. Klamo
,
T. Soderling
The Journal of biological chemistry
1994
Corpus ID: 46491918
Highly Cited
1994
Highly Cited
1994
A role for protein kinases and phosphatases in the Ca2+-induced enhancement of hippocampal AMPA receptor-mediated synaptic responses
D. Wyllie
,
R. Nicoll
Neuron
1994
Corpus ID: 33049899
Highly Cited
1992
Highly Cited
1992
Phosphorylation of myosin light chain kinase by the multifunctional calmodulin-dependent protein kinase II in smooth muscle cells.
M. Tansey
,
R. Word
,
+4 authors
J. Stull
The Journal of biological chemistry
1992
Corpus ID: 23351820
Highly Cited
1992
Highly Cited
1992
Inhibition of voltage-gated Ca2+ channels and insulin secretion in HIT cells by the Ca2+/calmodulin-dependent protein kinase II inhibitor KN-62: comparison with antagonists of calmodulin and L-type…
G. Li
,
H. Hidaka
,
C. Wollheim
Molecular pharmacology
1992
Corpus ID: 25288408
To probe for the involvement of Ca2+/calmodulin-dependent protein kinase II in the regulation of insulin secretion, the effects…
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Highly Cited
1991
Highly Cited
1991
The newly synthesized selective Ca2+/calmodulin dependent protein kinase II inhibitor KN-93 reduces dopamine contents in PC12h cells.
M. Sumi
,
K. Kiuchi
,
+4 authors
H. Hidaka
Biochemical and biophysical research…
1991
Corpus ID: 1810691
Highly Cited
1990
Highly Cited
1990
KN-62, 1-[N,O-bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpiperazi ne, a specific inhibitor of Ca2+/calmodulin-dependent protein kinase II.
H. Tokumitsu
,
T. Chijiwa
,
M. Hagiwara
,
A. Mizutani
,
M. Terasawa
,
H. Hidaka
The Journal of biological chemistry
1990
Corpus ID: 33649011
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