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KN 62

Known as: 5-Isoquinolinesulfonic acid, 4-(2-((5-isoquinolinylsulfonyl)methylamino)-3-oxo-3-(4-phenyl-1-piperazinyl)propyl)phenyl ester, (S)-, KN-62, KN62 compound 
National Institutes of Health

Papers overview

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Highly Cited
2008
Highly Cited
2008
Pannexin 1 (Panx1), an ortholog to invertebrate innexin gap junctions, has recently been proposed to be the pore induced by P2X(7… Expand
Highly Cited
2000
Highly Cited
2000
Long-term habituation to a novel environment is one of the most elementary forms of nonassociative learning. Here we studied the… Expand
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Highly Cited
1997
Highly Cited
1997
Long-term potentiation (LTP), a cellular model of learning and memory, requires calcium-dependent protein kinases. Induction of… Expand
Highly Cited
1997
Highly Cited
1997
Extracellular adenosine 5′‐triphosphate (ATP) is an agonist for a P2Z receptor on human lymphocytes which mediates opening of a… Expand
Highly Cited
1995
Highly Cited
1995
We have used monolayers of parental 3T3 fibroblasts and 3T3 cells expressing transfected cell adhesion molecules (CAMs, NCAM, N… Expand
Highly Cited
1994
Highly Cited
1994
We have characterized Ca2+/calmodulin-dependent protein kinase IV (CaM kinase IV), expressed using the baculovirus/Sf9 cell… Expand
Highly Cited
1992
Highly Cited
1992
To probe for the involvement of Ca2+/calmodulin-dependent protein kinase II in the regulation of insulin secretion, the effects… Expand
Highly Cited
1991
Highly Cited
1991
We reported that one of the isoquinolinesulfonamide derivatives, KN-62, is a potent and specific inhibitor of Ca2+/calmodulin… Expand
Highly Cited
1991
Highly Cited
1991
Effects of KN-62 (1-[NO-bis-1,5-isoquinolinesulfonyl]-N-methyl-L-tyrosyl- 4-phenylpiperazine), a specific inhibitor of calcium… Expand
Highly Cited
1990
Highly Cited
1990
1-[N,O-Bis(5-isoquinolinesulfonyl)-N-methyl-L-tyrosyl]-4-phenylpipera zine (KN-62), a selective inhibitor of rat brain Ca2… Expand