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KLHL3 gene
Known as:
KLHL3
, KIAA1129
, KELCH-LIKE 3
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National Institutes of Health
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects.
Waed Abdel Khalek
,
C. Rafael
,
+4 authors
X. Jeunemaître
Journal of the American Society of Nephrology…
2019
Corpus ID: 106408459
BACKGROUND Mutations in four genes, WNK lysine deficient protein kinase 1 and 4 (WNK1 and WNK4), kelch like family member 3…
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2017
2017
WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.
K. Susa
,
E. Sohara
,
Daiei Takahashi
,
T. Okado
,
T. Rai
,
S. Uchida
Biochemical and biophysical research…
2017
Corpus ID: 23055670
2017
2017
Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study
Lingyun Wang
,
Ji-Bin Peng
Protein science : a publication of the Protein…
2017
Corpus ID: 20816326
Interaction between the acidic motif (AM) of protein kinase WNK4 and the Kelch domain of KLHL3 are involved in the pathogenesis…
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2016
2016
A patient with pseudohypoaldosteronism type II complicated by congenital hypopituitarism carrying a KLHL3 mutation
M. Mitani
,
Munehiro Furuichi
,
+4 authors
Seiji Sato
Clinical pediatric endocrinology : case reports…
2016
Corpus ID: 13885943
Abstract. Pseudohypoaldosteronism type II (PHA II) is a renal tubular disease that causes hyperkalemia, hypertension, and…
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2015
2015
Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.
Y. Mori
,
Takayasu Mori
,
+5 authors
S. Uchida
The Biochemical journal
2015
Corpus ID: 37388024
We reported that kelch-like protein 3 (KLHL3)-Cullin3 E3 ligase ubiquitinates with-no-lysine kinase 4 (WNK4) and that impaired…
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2014
2014
Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome)
M. Glover
,
J. Ware
,
+11 authors
K. O'Shaughnessy
Clinical science
2014
Corpus ID: 1465472
The study of families with rare inherited forms of hypo- and hyper-tension has been one of the most successful strategies to…
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Highly Cited
2013
Highly Cited
2013
The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction
Akihito Ohta
,
Frances-Rose Schumacher
,
+6 authors
T. Kurz
The Biochemical journal
2013
Corpus ID: 15493129
The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1…
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2013
2013
Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ).
G. Rahman
,
S. Shanker
,
+5 authors
J. Das
The Biochemical journal
2013
Corpus ID: 11872153
PKC (protein kinase C) θ is predominantly expressed in T-cells and is critically involved in immunity. Design of PKCθ-selective…
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2013
2013
KLHL2 interacts with and ubiquitinates WNK kinases.
Daiei Takahashi
,
Takayasu Mori
,
+7 authors
S. Uchida
Biochemical and biophysical research…
2013
Corpus ID: 19289731
2000
2000
Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
F. Lai
,
B. Orelli
,
+4 authors
M. L. Le Beau
Genomics
2000
Corpus ID: 2807301
The Drosophila kelch protein is a structural component of ring canals and is required for oocyte maturation. Here, we report the…
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