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KLHL3 gene

Known as: KLHL3, KIAA1129, KELCH-LIKE 3 
 
National Institutes of Health

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2019
2019
Severe Arterial Hypertension from Cullin 3 Mutations Is Caused by Both Renal and Vascular Effects.
BACKGROUND Mutations in four genes, WNK lysine deficient protein kinase 1 and 4 (WNK1 and WNK4), kelch like family member 3… Expand
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2017
2017
Phosphorylation of KLHL3 at serine 433 impairs its interaction with the acidic motif of WNK4: a molecular dynamics study
  • L. Wang, J. Peng
  • Protein science : a publication of the Protein…
  • 2017
    • Corpus ID: 20816326
Interaction between the acidic motif (AM) of protein kinase WNK4 and the Kelch domain of KLHL3 are involved in the pathogenesis… Expand
2017
2017
WNK4 is indispensable for the pathogenesis of pseudohypoaldosteronism type II caused by mutant KLHL3.
WNK-OSR1/SPAK-NCC signaling cascade is important for regulating salt balance and blood pressure. Activation of WNK-OSR1/SPAK-NaCl… Expand
2016
2016
A patient with pseudohypoaldosteronism type II complicated by congenital hypopituitarism carrying a KLHL3 mutation
Abstract. Pseudohypoaldosteronism type II (PHA II) is a renal tubular disease that causes hyperkalemia, hypertension, and… Expand
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2015
2015
Involvement of selective autophagy mediated by p62/SQSTM1 in KLHL3-dependent WNK4 degradation.
We reported that kelch-like protein 3 (KLHL3)-Cullin3 E3 ligase ubiquitinates with-no-lysine kinase 4 (WNK4) and that impaired… Expand
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2014
2014
Detection of mutations in KLHL3 and CUL3 in families with FHHt (familial hyperkalaemic hypertension or Gordon's syndrome)
The study of families with rare inherited forms of hypo- and hyper-tension has been one of the most successful strategies to… Expand
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Highly Cited
2013
Highly Cited
2013
The CUL3–KLHL3 E3 ligase complex mutated in Gordon's hypertension syndrome interacts with and ubiquitylates WNK isoforms: disease-causing mutations in KLHL3 and WNK4 disrupt interaction
The WNK (with no lysine kinase)–SPAK (SPS1-related proline/alanine-rich kinase)/OSR1 (oxidative stress-responsive kinase 1… Expand
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2013
2013
Identification of the activator-binding residues in the second cysteine-rich regulatory domain of protein kinase Cθ (PKCθ).
PKC (protein kinase C) θ is predominantly expressed in T-cells and is critically involved in immunity. Design of PKCθ-selective… Expand
2013
2013
KLHL2 interacts with and ubiquitinates WNK kinases.
Mutations in the WNK1 and WNK4 genes result in an inherited hypertensive disease, pseudohypoaldosteronism type II (PHAII… Expand
2000
2000
Molecular characterization of KLHL3, a human homologue of the Drosophila kelch gene.
The Drosophila kelch protein is a structural component of ring canals and is required for oocyte maturation. Here, we report the… Expand
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