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KIAA1524 wt Allele

Known as: Autoantigen, 90-kD Gene, CIP2A, p90 
Human KIAA1524 wild-type allele is located in the vicinity of 3q13.13 and is approximately 44 kb in length. This allele, which encodes protein CIP2A… 
National Institutes of Health

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Broader (1)

KIAA1524 gene
Stimulation of Cell Proliferation

Papers overview

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2016
2016
High CIP2A levels correlate with an antiapoptotic phenotype that can be overcome by targeting BCL-XL in chronic myeloid leukemia
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a predictive biomarker of disease progression in many malignancies… 
2015
2015
c-Myc inhibition decreases CIP2A and reduces BCR-ABL1 tyrosine kinase activity in chronic myeloid leukemia
Chronic myeloid leukemia (CML) is a malignant disease of the primitive hematologic cell which is driven by BCR-ABL1 tyrosine… 
2014
2014
CIP2A is overexpressed in osteosarcoma and regulates cell proliferation and invasion
Cancerous inhibitor of protein phosphatase 2A (CIP2A) is a newly characterized oncoprotein involved in a variety of malignant… 
2014
2014
Expression patterns of microRNA-218 and its potential functions by targeting CIP2A and BMI1 genes in melanoma
Melanoma is the most aggressive skin cancer, and it is typically resistant or rapidly develops resistance to a variety of… 
2013
2013
Chk1 targeting reactivates PP2A tumor suppressor activity in cancer cells.
Checkpoint kinase Chk1 is constitutively active in many cancer cell types and new generation Chk1 inhibitors show marked… 
2013
2013
CIP2A expression and prognostic role in patients with esophageal adenocarcinoma
CIP2A is overexpressed in many cancers, including esophageal squamous cell carcinoma. The regulation of c-MYC and CIP2A… 
2012
2012
CIP2A with survivin protein expressions in human non-small-cell lung cancer correlates with prognosis
Cancerous inhibitor of protein phosphatase 2A (CIP2A) and survivin are aberrantly expressed in a wide range of human cancers… 
Highly Cited
2012
Highly Cited
2012
Identification of a c-Jun N-terminal kinase-2-dependent signal amplification cascade that regulates c-Myc levels in ras transformation
Ras is one of the most frequently activated oncogenes in cancer. Two mitogen-activated protein kinases (MAPKs) are important for… 
2012
2012
Expression and prognostic significance of CIP2A mRNA in hepatocellular carcinoma and nontumoral liver tissues
Objective: This study was undertaken to determine the role of cancerous inhibitor of protein phosphatase 2A (CIP2A) in predicting… 
Review
2011
Review
2011
A Novel SET Antagonist (OP449) Is Cytotoxic to CML Cells, Including the Highly-Resistant BCR-ABLT315I Mutant, and Demonstrates Enhanced Efficacy in Combination with ABL Tyrosine Kinase Inhibitors,
Abstract 3757 Background: The majority of patients with chronic myeloid leukemia (CML) achieve durable remissions with ABL… 
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