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The KCNE3 β-subunit constitutively opens outwardly rectifying KCNQ1 (Kv7.1) K+ channels by abolishing their voltage-dependent… Expand Background— The Brugada syndrome, an inherited syndrome associated with a high incidence of sudden cardiac arrest, has been… Expand KCNQ1 is a voltage-dependent K+ channel whose gating properties are dramatically altered by association with auxiliary KCNE… Expand OBJECTIVES
The function of Kv4.3 (KCND3) channels, which underlie the transient outward current I(to) in human heart, can be… Expand OBJECTIVE
The voltage-gated K+ channel KCNQ1 associates with the small KCNE1 beta subunit to underlie the IKs repolarizing… Expand BACKGROUND & AIMS
Gastric H+ secretion via the H+/K+-adenosine triphosphatase is coupled to the uptake of K+. However, the… Expand KvLQT1 is a Shaker-like voltage-gated potassium channel that when complexed with minK (KCNE1) produces the slowly activating… Expand Abstract. The KCNQ1 potassium channel α-subunit can associate with various KCNE β-subunits that drastically influence channel… Expand Mutations in all four known KCNQ potassium channel α-subunit genes lead to human diseases. KCNQ1 (KvLQT1) interacts with the… Expand Mutations in HERG and KCNQ1 (or KVLQT1) genes cause the life‐threatening Long QT syndrome. These genes encode K+ channel pore… Expand