JUP protein, human

Known as: JUP, Desmoplakin-3, Plakoglobin 
Junction plakoglobin (744 aa, ~82 kDa) is encoded by the human JUP gene. This protein is involved in adherens junction assembly.
National Institutes of Health

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12 relations
Cell AdhesionClusters of differentiationDesmosomeHomo sapiens
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Broader (2)

desmoplakinplakoglobin

Papers overview

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Highly Cited
2012
Highly Cited
2012
A mechanoresponsive cadherin-keratin complex directs polarized protrusive behavior and collective cell migration.
Collective cell migration requires maintenance of adhesive contacts between adjacent cells, coordination of polarized cell… (More)
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Highly Cited
2002
Highly Cited
2002
Mutation in human desmoplakin domain binding to plakoglobin causes a dominant form of arrhythmogenic right ventricular cardiomyopathy.
Arrhythmogenic right ventricular cardiomyopathy (ARVD/C) is a genetically heterogeneous disease characterized by progressive… (More)
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Highly Cited
2001
Highly Cited
2001
Phosphatidylinositol 4,5-bisphosphate and Arf6-regulated membrane traffic
ADP-ribosylation factor (Arf) 6 regulates the movement of membrane between the plasma membrane (PM) and a nonclathrin-derived… (More)
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Highly Cited
2000
Highly Cited
2000
The glomerular slit diaphragm is a modified adherens junction.
The glomerular slit diaphragm between podocyte foot processes shares typical morphologic features with an adherens junction… (More)
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Highly Cited
1998
Highly Cited
1998
Vascular endothelial growth factor induces VE-cadherin tyrosine phosphorylation in endothelial cells.
Interendothelial junctions play an important role in the regulation of endothelial functions, such as vasculogenesis… (More)
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Highly Cited
1995
Highly Cited
1995
The molecular organization of endothelial cell to cell junctions: differential association of plakoglobin, beta-catenin, and alpha- catenin with vascular endothelial cadherin (VE-cadherin)
In this paper we report that the assembly of interendothelial junctions containing the cell type-specific vascular endothelial… (More)
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Highly Cited
1994
Highly Cited
1994
E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton
beta-Catenin is involved in the formation of adherens junctions of mammalian epithelia. It interacts with the cell adhesion… (More)
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Highly Cited
1994
Highly Cited
1994
Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly
Calcium-dependent cell-cell adhesion is mediated by the cadherin family of cell adhesion proteins. Transduction of cadherin… (More)
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Highly Cited
1990
Highly Cited
1990
The segment polarity gene armadillo encodes a functionally modular protein that is the Drosophila homolog of human plakoglobin.
The Drosophila segment polarity gene armadillo is required for pattern formation within embryonic segments and imaginal discs. We… (More)
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Highly Cited
1986
Highly Cited
1986
Plakoglobin: A protein common to different kinds of intercellular adhering junctions
We have established, by means of a monoclonal antibody and a cDNA clone, that a desmosomal polypeptide of Mr 83,000 also occurs… (More)
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