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JNJ-40411813

 
National Institutes of Health

Papers overview

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Review
2019
Review
2019
mGluR2 positive allosteric modulators: an updated patent review (2013-2018).
Introduction: Positive allosteric modulation of mGlu2 has attracted much interest as an alternative approach to classical… Expand
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Review
2018
Review
2018
Progress report on new antiepileptic drugs: A summary of the Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV). I. Drugs in preclinical and early clinical development
The Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV) took place in Madrid, Spain, on May 13-16… Expand
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2017
2017
Efficacy of mGlu2‐positive allosteric modulators alone and in combination with levetiracetam in the mouse 6 Hz model of psychomotor seizures
OBJECTIVE The metabotropic glutamate receptor subtype 2 (mGlu2 ) possesses both orthosteric and allosteric modulatory sites, are… Expand
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2017
2017
A Roadmap for Development of Novel Antipsychotic Agents Based on a Risperidone Scaffold
A ROADMAP FOR DEVELOPMENT OF NOVEL ANTIPSYCHOTIC AGENTS BASED ON A RISPERIDONE SCAFFOLD By Urjita H. Shah, Ph. D. A dissertation… Expand
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2016
2016
Efficacy and safety of an adjunctive mGlu2 receptor positive allosteric modulator to a SSRI/SNRI in anxious depression
This phase 2a, randomized, multicenter, double-blind, proof-of-concept study was designed to evaluate, efficacy, safety and… Expand
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2016
2016
Translational neurophysiological markers for activity of the metabotropic glutamate receptor (mGluR2) modulator JNJ-40411813: Sleep EEG correlates in rodents and healthy men
Alterations in rapid eye movement sleep (REM) have been suggested as valid translational efficacy markers: activation of the… Expand
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2015
2015
Preclinical evaluation of the antipsychotic potential of the mGlu2-positive allosteric modulator JNJ-40411813
JNJ-40411813/ADX71149 (1-butyl-3-chloro-4-(4-phenylpiperidin-1-yl) pyridin-2(1H)-one) is a positive allosteric modulator (PAM) of… Expand
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2015
2015
Pharmacokinetic and pharmacodynamic characterisation of JNJ-40411813, a positive allosteric modulator of mGluR2, in two randomised, double-blind phase-I studies
Metabotropic glutamate receptor-2 positive allosteric modulator, JNJ-40411813 (ADX71149), was characterised for clinical effects… Expand
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2015
2015
Pharmacological and pharmacokinetic properties of JNJ-40411813, a positive allosteric modulator of the mGlu2 receptor
Compounds modulating metabotropic glutamate type 2 (mGlu2) receptor activity may have therapeutic benefits in treating… Expand
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2014
2014
Discovery of 1-butyl-3-chloro-4-(4-phenyl-1-piperidinyl)-(1H)-pyridone (JNJ-40411813): a novel positive allosteric modulator of the metabotropic glutamate 2 receptor.
We previously reported the discovery of 4-aryl-substituted pyridones with mGlu2 PAM activity starting from the HTS hit 5. In this… Expand
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