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JNJ-40411813

National Institutes of Health

Papers overview

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Review
2019
Review
2019
ABSTRACT Introduction: Positive allosteric modulation of mGlu2 has attracted much interest as an alternative approach to… 
Review
2018
Review
2018
The Fourteenth Eilat Conference on New Antiepileptic Drugs and Devices (EILAT XIV) took place in Madrid, Spain, on May 13‐16… 
Review
2017
Review
2017
Clinical and preclinical studies suggest that dysfunction of the glutamatergic system is implicated in mood disorders such as… 
2017
2017
The metabotropic glutamate receptor subtype 2 (mGlu2) possesses both orthosteric and allosteric modulatory sites, are expressed… 
2015
2015
JNJ‐40411813/ADX71149 (1‐butyl‐3‐chloro‐4‐(4‐phenylpiperidin‐1‐yl) pyridin‐2(1H)‐one) is a positive allosteric modulator (PAM) of… 
2015
2015
Metabotropic glutamate receptor-2 positive allosteric modulator, JNJ-40411813 (ADX71149), was characterised for clinical effects… 
2014
2014
We previously reported the discovery of 4-aryl-substituted pyridones with mGlu2 PAM activity starting from the HTS hit 5. In this… 
2014
2014
Compounds modulating metabotropic glutamate type 2 (mGlu2) receptor activity may have therapeutic benefits in treating…