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JNJ 10198409
Known as:
JNJ-10198409
, JNJ10198409
National Institutes of Health
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2012
2012
Oral coadministration of β-glucuronidase to increase exposure of extensively glucuronidated drugs that undergo enterohepatic recirculation.
G. Eichenbaum
,
C.-P. Hsu
,
+5 authors
Dana L. Johnson
Journal of Pharmacy and Science
2012
Corpus ID: 20067314
Extensive first-pass metabolism can significantly limit a drug's oral exposure levels. In this work, we introduce an innovative…
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2006
2006
N-GLUCURONIDATION OF THE PLATELET-DERIVED GROWTH FACTOR RECEPTOR TYROSINE KINASE INHIBITOR 6,7-(DIMETHOXY-2,4-DIHYDROINDENO[1,2-C]PYRAZOL-3-YL)-(3-FLUORO-PHENYL)-AMINE BY HUMAN UDP…
Zhengyin Yan
,
Gary W. Caldwell
,
+8 authors
D. Johnson
Drug Metabolism And Disposition
2006
Corpus ID: 5996396
The potential cancer therapeutic agent, 6,7-(dimethoxy-2, 4-dihydroindeno[1,2-c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine (JNJ…
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2006
2006
DMD # 9274 1 N-Glucuronidation of the PDGF Receptor Tyrosine Kinase Inhibitor 6 , 7-( Dimethoxy-2 , 4-dihydroindeno [ 1 , 2-c ] pyrazol-3-yl )-( 3-fluoro-phenyl )-amine by Human UDP…
Z. Yan
,
G. Caldwell
,
+8 authors
D. Johnson
2006
Corpus ID: 28566292
The potential cancer therapeutic agent, 6,7-(dimethoxy-2,4-dihydroindeno[1,2c]pyrazol-3-yl)-(3-fluoro-phenyl)-amine (JNJ-10198409…
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2005
2005
Validation of in vivo pharmacodynamic activity of a novel PDGF receptor tyrosine kinase inhibitor using immunohistochemistry and quantitative image analysis
M. D'Andrea
,
J. Mei
,
R. Tuman
,
R. Galemmo
,
Dana L. Johnson
Molecular Cancer Therapeutics
2005
Corpus ID: 21777015
With the advent of agents directed against specific molecular targets in drug discovery, it has become imperative to show a…
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