JAK2 NP_004963.1:p.V617F

Known as: Janus Kinase 2 V617F, Tyrosine-Protein Kinase JAK2 V617F, JAK2 p.V617F 
A change in the amino acid residue at position 617 in the tyrosine-protein kinase JAK2 protein where valine has been replaced by phenylalanine.
National Institutes of Health

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Highly Cited
2014
Highly Cited
2014
Myeloproliferative neoplasms (MPNs) are a group of clonal disorders characterized by aberrant hematopoietic proliferation and an… (More)
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Highly Cited
2011
Highly Cited
2011
PURPOSE Myelofibrosis is a myeloid malignancy associated with anemia, splenomegaly, and constitutional symptoms. Patients… (More)
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Highly Cited
2011
Highly Cited
2011
Chronic myelomonocytic leukemia (CMML), a myelodysplastic/myeloproliferative neoplasm, is characterized by monocytic… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Myelofibrosis is a Philadelphia chromosome–negative myeloproliferative neoplasm associated with cytopenias… (More)
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Highly Cited
2010
Highly Cited
2010
Somatic mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) were recently demonstrated in acute myeloid leukemia (AML… (More)
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Highly Cited
2010
Highly Cited
2010
Dysregulated Janus kinase-signal transducer and activator of transcription (JAK-STAT) signaling due to activation of tyrosine… (More)
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Highly Cited
2005
Highly Cited
2005
BACKGROUND An acquired V617F mutation in JAK2 occurs in most patients with polycythaemia vera, but is seen in only half those… (More)
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Highly Cited
2005
Highly Cited
2005
The analysis of rare chromosomal translocations in myeloproliferative disorders has highlighted the importance of aberrant… (More)
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Highly Cited
2005
Highly Cited
2005
A somatic mutation in the JH2 autoinhibitory domain of the Janus kinase 2 (JAK2) tyrosine kinase was recently described in… (More)
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Highly Cited
2001
Highly Cited
2001
Erythropoietin, a kidney cytokine regulating haematopoiesis (the production of blood cells), is also produced in the brain after… (More)
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