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Isocitrate Dehydrogenase [NADP] Cytoplasmic

Known as: IDH, EC 1.1.1.42, NADP (+)-specific ICDH 
Isocitrate dehydrogenase [NADP] cytoplasmic (414 aa, 47 kDa) is encoded by the human IDH1 gene. This protein plays a role the oxidation of isocitrate… Expand
National Institutes of Health

Papers overview

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Review
2019
Review
2019
Glioblastoma (GBM) is one of the most aggressive and lethal human brain tumors. At present, GBMs are divided in primary and… Expand
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Review
2018
Review
2018
Anticancer target drugs (ATDs) specifically bind and inhibit molecular targets that play important roles in cancer development… Expand
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Review
2017
Review
2017
Purpose: Lower-grade gliomas (WHO grade II/III) have been classified into clinically relevant molecular subtypes based on IDH and… Expand
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Review
2016
Review
2016
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical… Expand
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health… Expand
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… Expand
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Highly Cited
2010
Highly Cited
2010
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe… Expand
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Highly Cited
2010
Highly Cited
2010
Cancer-associated IDH mutations are characterized by neomorphic enzyme activity and resultant 2-hydroxyglutarate (2HG) production… Expand
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Highly Cited
2009
Highly Cited
2009
BACKGROUND A recent genomewide mutational analysis of glioblastomas (World Health Organization [WHO] grade IV glioma) revealed… Expand
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Highly Cited
2009
Highly Cited
2009
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain… Expand
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