Isocitrate Dehydrogenase [NADP] Cytoplasmic

Known as: IDH, EC 1.1.1.42, NADP (+)-specific ICDH 
Isocitrate dehydrogenase [NADP] cytoplasmic (414 aa, 47 kDa) is encoded by the human IDH1 gene. This protein plays a role the oxidation of isocitrate… (More)
National Institutes of Health

Papers overview

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Review
2016
Review
2016
The 2016 World Health Organization Classification of Tumors of the Central Nervous System is both a conceptual and practical… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND Diffuse low-grade and intermediate-grade gliomas (which together make up the lower-grade gliomas, World Health… (More)
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Highly Cited
2015
Highly Cited
2015
BACKGROUND The prediction of clinical behavior, response to therapy, and outcome of infiltrative glioma is challenging. On the… (More)
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Review
2013
Review
2013
Mutations in isocitrate dehydrogenase (IDH) 1 and 2, originally discovered in 2008, occur in the vast majority of low-grade… (More)
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… (More)
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Highly Cited
2011
Highly Cited
2011
Point mutations of the NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) occur early in the pathogenesis of… (More)
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Highly Cited
2010
Highly Cited
2010
The Cancer Genome Atlas Network recently cataloged recurrent genomic abnormalities in glioblastoma multiforme (GBM). We describe… (More)
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Highly Cited
2010
Highly Cited
2010
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), are present in most gliomas and secondary glioblastomas, but are rare in… (More)
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Highly Cited
2010
Highly Cited
2010
The somatic mutations in cytosolic isocitrate dehydrogenase 1 (IDH1) observed in gliomas can lead to the production of 2… (More)
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Highly Cited
2009
Highly Cited
2009
PURPOSE Unexpected mutations affecting the isocitrate dehydrogenase (IDH1) gene at codon 132 have been found in 12% of… (More)
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