Isocitrate Dehydrogenase (NAD+)

Known as: Dehydrogenase, NAD Isocitrate, Isocitrate:NAD+ oxidoreductase (decarboxylating), Isocitrate Dehydrogenase [Chemical/Ingredient] 
An enzyme of the oxidoreductase class that catalyzes the conversion of isocitrate and NAD+ to yield 2-ketoglutarate, carbon dioxide, and NADH. It… (More)
National Institutes of Health

Topic mentions per year

Topic mentions per year

1960-2018
010020019602018

Papers overview

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Review
2016
Review
2016
Over the last decade, extraordinary progress has been made in elucidating the underlying genetic causes of gliomas. In 2008, our… (More)
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Highly Cited
2012
Highly Cited
2012
Both genome-wide genetic and epigenetic alterations are fundamentally important for the development of cancers, but the… (More)
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Highly Cited
2012
Highly Cited
2012
Recurrent mutations in isocitrate dehydrogenase 1 (IDH1) and IDH2 have been identified in gliomas, acute myeloid leukaemias (AML… (More)
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Highly Cited
2012
Highly Cited
2012
Mitochondria play a central role in oxidative energy metabolism and age-related diseases such as cancer. Accumulation of spurious… (More)
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Highly Cited
2011
Highly Cited
2011
Citrate is a critical metabolite required to support both mitochondrial bioenergetics and cytosolic macromolecular synthesis… (More)
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Highly Cited
2011
Highly Cited
2011
Point mutations of the NADP(+)-dependent isocitrate dehydrogenases 1 and 2 (IDH1 and IDH2) occur early in the pathogenesis of… (More)
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Highly Cited
2010
Highly Cited
2010
Mutations in isocitrate dehydrogenase 1 and 2 (IDH1/2), are present in most gliomas and secondary glioblastomas, but are rare in… (More)
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Highly Cited
2009
Highly Cited
2009
Mutations in the enzyme cytosolic isocitrate dehydrogenase 1 (IDH1) are a common feature of a major subset of primary human brain… (More)
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Highly Cited
2008
Highly Cited
2008
Glioblastoma multiforme (GBM) is the most common and lethal type of brain cancer. To identify the genetic alterations in GBMs, we… (More)
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Highly Cited
1976
Highly Cited
1976
1. The activities of citrate synthase, NAD+-linked and NADP+-linked isocitrate dehydrogenase were measured in muscles from a… (More)
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