Isoacitretin

LC- ESI- MS/MS simultaneous bioanalytical method was developed to determine acitretin and its metabolite isoacitretin in human… (More)

Male Sprague-Dawley rats were pretreated with either phenobarbital (PB) or beta-naphthoflavone (BNF), after which acitretin (0.84… (More)

Certain retinoids have been shown in rats and mice to induce the hepatic cytochrome P-450 enzyme system, and evidence from our… (More)

The disposition of the antipsoriatic agent, acitretin, was investigated in six healthy human volunteers who each received a… (More)

1. The metabolism of acitretin and its 13-cis isomer, isoacitretin, has been investigated in the in situ isolated perfused rat… (More)

The ability of glutathione to catalyze the cis-trans isomerization of acitretin and isoacitretin was explored. Glutathione… (More)

Etretinate accumulates in adipose tissue; this appears to account for its long terminal elimination phase in psoriatic patients… (More)

Five metabolites were isolated from the blood of psoriatic patients on chronic therapy with etretinate (Tegison). The two major… (More)

The metabolites of etretinate (Tegison) were investigated in bile obtained from two patients with biliary T-tubes. Bile samples… (More)