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During the past decade, skeletal muscle has been identified as a secretory organ. Accordingly, we have suggested that cytokines… Expand Components of the immune system are altered in obesity and type 2 diabetes (T2D), with the most apparent changes occurring in… Expand In vivo protein-DNA interactions connect each transcription factor with its direct targets to form a gene network scaffold. To… Expand Obesity is associated with an increased risk of developing insulin resistance and type 2 diabetes. In obese individuals, adipose… Expand In this contribution we put forward a novel hypothesis concerning the aetiology of Type 2 (non-insulin-dependent) diabetes… Expand MicroRNAs (miRNAs) constitute a growing class of non-coding RNAs that are thought to regulate gene expression by translational… Expand Although the source of embryonic stem (ES) cells presents ethical concerns, their use may lead to many clinical benefits if… Expand During carcinogenesis of pancreatic islets in transgenic mice, an angiogenic switch activates the quiescent vasculature… Expand IT is now well established that unrestricted growth of tumours is dependent upon angiogenesis1,2. Previous studies on tumour… Expand Amyloid deposits localized to the islets of Langerhans are typical of non-insulin-dependent human diabetes mellitus and of… Expand