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Islet Amyloid Polypeptide, human

Known as: Insulinoma Amyloid Peptide, Amylin, Diabetes-Associated Peptide 
Islet amyloid polypeptide (89 aa, ~10 kDa) is encoded by the human IAPP gene. This protein plays a role in the regulation of glucose metabolism.
National Institutes of Health

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7 relations
AmylinApoptosisExtracellular SpaceIAPP gene

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Review
2016
Review
2016
Cistrome and Epicistrome Features Shape the Regulatory DNA Landscape
Review
2011
Review
2011
Islet amyloid polypeptide, islet amyloid, and diabetes mellitus.
Islet amyloid polypeptide (IAPP, or amylin) is one of the major secretory products of β-cells of the pancreatic islets of… 
Review
2009
Review
2009
How ERK1/2 activation controls cell proliferation and cell death: Is subcellular localization the answer?
Extracellular signal-regulated protein kinases 1 and 2 (ERK1/2) are members of the mitogen-activated protein kinase super family… 
Highly Cited
2008
Highly Cited
2008
Molecular structural basis for polymorphism in Alzheimer's β-amyloid fibrils
We describe a full structural model for amyloid fibrils formed by the 40-residue β-amyloid peptide associated with Alzheimer's… 
Highly Cited
2005
Highly Cited
2005
Amyloid ion channels: a common structural link for protein-misfolding disease.
Protein conformational diseases, including Alzheimer's, Huntington's, and Parkinson's diseases, result from protein misfolding… 
Review
2004
Review
2004
Autophagy as a cell death and tumor suppressor mechanism
Autophagy is characterized by sequestration of bulk cytoplasm and organelles in double or multimembrane autophagic vesicles, and… 
Highly Cited
2002
Highly Cited
2002
Modeling the excitability of mammalian nerve fibers: influence of afterpotentials on the recovery cycle.
Human nerve fibers exhibit a distinct pattern of threshold fluctuation following a single action potential known as the recovery… 
Review
1999
Review
1999
Islet amyloid: a long-recognized but underappreciated pathological feature of type 2 diabetes.
Islet amyloid has been recognized as a pathological entity in type 2 diabetes since the turn of the century. It has as its unique… 
Highly Cited
1996
Highly Cited
1996
Islet amyloid formation associated with hyperglycemia in transgenic mice with pancreatic beta cell expression of human islet amyloid polypeptide.
Pancreatic islet amyloid deposits are a characteristic pathologic feature of non-insulin-dependent diabetes mellitus and contain… 
Highly Cited
1987
Highly Cited
1987
Purification and characterization of a peptide from amyloid-rich pancreases of type 2 diabetic patients.
Deposition of amyloid in pancreatic islets is a common feature in human type 2 diabetic subjects but because of its insolubility… 
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