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Iron Regulatory Protein 2
Known as:
IRE-BP2
, IRP-2 RNA-binding protein
, IREB2 Protein
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A multifunctional iron-sulfur protein that is both an iron regulatory protein and cytoplasmic form of aconitate hydratase. It binds to iron…
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National Institutes of Health
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Related topics
Related topics
9 relations
IREB2 gene
In Blood
Process of secretion
agonists
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2017
Highly Cited
2017
Ferredoxin reductase is critical for p53-dependent tumor suppression via iron regulatory protein 2
Yanhong Zhang
,
Yingjuan Qian
,
+9 authors
Xinbin Chen
Genes & Development
2017
Corpus ID: 29108238
In this study, Chen and colleagues investigated the biological function of ferredoxin reductase (FDXR), a target of p53. They…
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Highly Cited
2009
Highly Cited
2009
Control of Iron Homeostasis by an Iron-Regulated Ubiquitin Ligase
A. Vashisht
,
Kimberly B. Zumbrennen
,
+10 authors
J. Wohlschlegel
Science
2009
Corpus ID: 45503037
Iron Sensor Intracellular iron is an essential cofactor for many proteins, but can also damage macromolecules, so its levels are…
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Highly Cited
2009
Highly Cited
2009
Coordination of PGC-1β and iron uptake in mitochondrial biogenesis and osteoclast activation
Kiyo-aki Ishii
,
Toshio Fumoto
,
+8 authors
K. Ikeda
Nature Network Boston
2009
Corpus ID: 205386105
Osteoclasts are acid-secreting polykaryons that have high energy demands and contain abundant mitochondria. How mitochondrial…
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Highly Cited
2006
Highly Cited
2006
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse
B. Galy
,
S. Hölter
,
+6 authors
M. Hentze
Nature Genetics
2006
Corpus ID: 10642422
Iron homeostasis in the brain: complete iron regulatory protein 2 deficiency without symptomatic neurodegeneration in the mouse
Highly Cited
2005
Highly Cited
2005
Altered body iron distribution and microcytosis in mice deficient in iron regulatory protein 2 (IRP2).
B. Galy
,
Dunja Ferring
,
+5 authors
M. Hentze
Blood
2005
Corpus ID: 32823204
Iron regulatory protein 2 (IRP2)-deficient mice have been reported to suffer from late-onset neurodegeneration by an unknown…
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Highly Cited
2003
Highly Cited
2003
Oxygen and Iron Regulation of Iron Regulatory Protein 2*
E. Hanson
,
M. L. Rawlins
,
E. A. Leibold
Journal of Biological Chemistry
2003
Corpus ID: 8875272
Iron regulatory protein 2 (IRP2) is a central regulator of cellular iron homeostasis due to its regulation of specific mRNAs…
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Highly Cited
1998
Highly Cited
1998
Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: implications for degradation of oxidized proteins.
K. Iwai
,
S. K. Drake
,
+6 authors
T. Rouault
Proceedings of the National Academy of Sciences…
1998
Corpus ID: 25418464
The ability of iron to catalyze formation of reactive oxygen species significantly contributes to its toxicity in cells and…
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Highly Cited
1995
Highly Cited
1995
Iron Regulates the Intracellular Degradation of Iron Regulatory Protein 2 by the Proteasome (*)
B. Guo
,
J. Phillips
,
Yang Yu
,
E. A. Leibold
Journal of Biological Chemistry
1995
Corpus ID: 40443580
Iron regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to specific structures, termed iron-responsive…
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Highly Cited
1995
Highly Cited
1995
Characterization and Expression of Iron Regulatory Protein 2 (IRP2).
B. Guo
,
Fritz M. Brown
,
J. Phillips
,
Yang Yu
,
E. A. Leibold
Journal of Biological Chemistry
1995
Corpus ID: 22702914
Iron regulatory proteins (IRP1 and IRP2) are RNA-binding proteins that bind to stem-loop structures, termed iron-responsive…
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Highly Cited
1995
Highly Cited
1995
Requirements for iron‐regulated degradation of the RNA binding protein, iron regulatory protein 2.
K. Iwai
,
R. Klausner
,
T. Rouault
EMBO Journal
1995
Corpus ID: 22291808
Iron regulatory proteins (IRPs) regulate the expression of genes involved in iron metabolism whose transcripts contain RNA stem…
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