Investigational New Drugs

Known as: Investigational Drugs, drugs investigational, Drugs, Investigational New 
A substance that has been tested in a laboratory and has gotten approval from the U.S. Food and Drug Administration (FDA) to be tested in people. An… (More)
National Institutes of Health

Papers overview

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Highly Cited
2011
Highly Cited
2011
OBJECTIVE There has been concern about a high rate of placebo response and a substantial failure rate in recent clinical trials… (More)
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Review
2010
Review
2010
This study utilizes both public and private data sources to estimate clinical phase transition and clinical approval… (More)
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Highly Cited
2010
Highly Cited
2010
BACKGROUND Linaclotide is a novel, orally administered investigational drug currently in clinical development for the treatment… (More)
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Highly Cited
2009
Highly Cited
2009
Although drugs are intended to be selective, at least some bind to several physiological targets, explaining side effects and… (More)
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Highly Cited
2009
Highly Cited
2009
Therapeutic decision-making in primary myelofibrosis (PMF) is becoming more challenging because of the increasing use of… (More)
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Highly Cited
2009
Highly Cited
2009
BACKGROUND CONTEXT Cervical total disc replacement (TDR) is intended to address radicular pain and preserve functional motion… (More)
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Highly Cited
2002
Highly Cited
2002
We examine the effect of securities laws on stock market development in 49 countries. We find almost no evidence that public… (More)
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Highly Cited
2002
Highly Cited
2002
Traditional phase I studies find the therapeutic dose of an investigational drug based solely on toxicity and without regard to… (More)
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Highly Cited
2001
Highly Cited
2001
BACKGROUND The role of bone morphogenetic proteins (BMPs) in osseous repair has been demonstrated in numerous animal models… (More)
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Highly Cited
2001
Highly Cited
2001
 
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