Interleukin-12 Subunit p40

Known as: Interleukin 12 beta Chain, IL-12p40, Interleukin 12 Subunit p40 
A cytokine subunit that is a component of both interleukin-12 and interleukin-23. It binds to the INTERLEUKIN-12 SUBUNIT P35 via a disulfide bond to… (More)
National Institutes of Health

Papers overview

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Highly Cited
2006
Highly Cited
2006
A new lineage of effector CD4+ T cells characterized by production of interleukin (IL)-17, the T-helper-17 (T(H)17) lineage, was… (More)
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Highly Cited
2002
Highly Cited
2002
IL-23 is a heterodimeric cytokine composed of the IL-12p40 "soluble receptor" subunit and a novel cytokine-like subunit related… (More)
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Highly Cited
2001
Highly Cited
2001
Interleukin-12 p70 (IL-12p70) heterodimer, composed of p35 and p40 subunits, is a major Th1-driving cytokine, promoting cell… (More)
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Highly Cited
2000
Highly Cited
2000
A novel sequence discovered in a computational screen appears distantly related to the p35 subunit of IL-12. This factor, which… (More)
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Highly Cited
2000
Highly Cited
2000
Owing to the importance of interleukin (IL)-12 in regulating immune responses, we have determined the complete genomic sequence… (More)
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Highly Cited
1998
Highly Cited
1998
To analyze the roles of interleukin-12 (IL-12) and the IL-12-dependent Th1 response in resistance to Cryptococcus neoformans, we… (More)
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Highly Cited
1997
Highly Cited
1997
The bioactivity of IL-12 is mediated by heterodimers of disulfide-linked p35 and p40 protein subunits. Homodimeric p40 competes… (More)
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Highly Cited
1995
Highly Cited
1995
Interleukin-12 (IL-12) is a cytokine that has regulatory effects on T and natural killer (NK) cells and is composed of two… (More)
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Highly Cited
1995
Highly Cited
1995
Pathogenic bacteria that penetrate the intestinal epithelial barrier stimulate an inflammatory response in the adjacent… (More)
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Highly Cited
1993
Highly Cited
1993
The recently discovered cytokine interleukin (IL)-12 is a heterodimeric protein of two disulfide-bonded subunits of 35 and 40 kDa… (More)
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