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Interleukin-1 Receptor-Associated Kinase 2

Known as: IRAK 2 Kinase, Interleukin 1 Receptor Associated Kinase 2, IRAK-2 Kinase 
Interleukin-1 receptor-associated kinase-like 2 (625 aa, ~70 kDa) is encoded by the human IRAK2 gene. This protein is involved in signaling.
National Institutes of Health

Papers overview

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Review
2010
Review
2010
The interleukin receptor-associated kinase (IRAK) family are involved in regulating Toll-like receptor (TLR) and interleukin-1… Expand
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Highly Cited
2010
Highly Cited
2010
MyD88, IRAK4 and IRAK2 are critical signalling mediators of the TLR/IL1-R superfamily. Here we report the crystal structure of… Expand
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Highly Cited
2010
Highly Cited
2010
Specific microRNAs (miRNAs), small non-coding RNAs that support homeostatic gene expression, are significantly altered in… Expand
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Highly Cited
2009
Highly Cited
2009
Upon recognition of viral components by pattern recognition receptors, including TLRs and retinoic acid-inducible gene I (RIG-I… Expand
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2009
2009
IRAK2, a member of the interleukin-1 receptor-associated kinase (IRAK) family, has been implicated in Toll-like receptor (TLR… Expand
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Highly Cited
2005
Highly Cited
2005
The interleukin-1 (IL-1) receptor-associated kinase 1 (IRAK1) is a member of the IRAK kinase family that plays a pivotal role in… Expand
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Highly Cited
2001
Highly Cited
2001
The recognition of microbial pathogens by the innate immune system involves Toll-like receptors (TLRs), which recognize pathogen… Expand
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Highly Cited
1999
Highly Cited
1999
The interleukin-1 receptor-associated kinase (IRAK) was first described as a signal transducer for interleukin-1 (IL-1) and has… Expand
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Highly Cited
1999
Highly Cited
1999
Bacterial lipopolysaccharide (LPS)-mediated immune responses, including activation of monocytes, macrophages, and endothelial… Expand
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Highly Cited
1997
Highly Cited
1997
The interleukin-1 receptor (IL-1R) signaling pathway leads to nuclear factor kappa B (NF-kappaB) activation in mammals and is… Expand
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