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Insulin-Like Growth Factor 1 Receptor Beta Chain, Human

Known as: IGF1R Beta Chain, CD221 Antigen Beta Chain, IGF-IR Beta Chain 
Insulin-like growth factor 1 receptor beta chain (627 aa, ~71 kDa) is encoded by the human IGF1R gene. This protein plays a role in growth factor… Expand
National Institutes of Health

Related topics

Related topics

19 relations
Cell Differentiation processCell ProliferationCell Proliferation Regulatory ProcessEnzyme Gene
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Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
2020
2020
Antagonistic Autoantibodies to Insulin-Like Growth Factor-1 Receptor Associate with Poor Physical Strength
Natural autoantibodies to the IGF1 receptor (IGF1R-aAb) have been described in relation to Graves’ ophthalmopathy. Other… Expand
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2017
2017
Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies
Background: The growth-promoting effects of IGF-I is mediated through the IGF-I receptor (IGF1R), a widely expressed cell-surface… Expand
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2017
2017
Supplementary Material for: Expanding Genetic and Functional Diagnoses of IGF1R Haploinsufficiencies
 
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2010
2010
Insulin-like growth factor axis gene polymorphisms and clinical outcomes in pancreatic cancer.
BACKGROUND & AIMS Insulin-like growth factor (IGF)-axis mediated signaling pathways play an important role in pancreatic cancer… Expand
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Review
2009
Review
2009
Two short children born small for gestational age with insulin-like growth factor 1 receptor haploinsufficiency illustrate the heterogeneity of its phenotype.
CONTEXT Small for gestational age (SGA)-born children comprise a heterogeneous group in which only few genetic causes have been… Expand
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2008
2008
Modification of IGF1R Expression on Malignant Lymphoid Cells by a Proteasome Inhibitor
Purpose: The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase, which is overexpressed by tumors, and mediates… Expand
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Highly Cited
1998
Highly Cited
1998
Protein Kinase C-δ Is an Important Signaling Molecule in Insulin-Like Growth Factor I Receptor-Mediated Cell Transformation
ABSTRACT To investigate the potential role of protein kinase C-δ (PKC-δ) in insulin-like growth factor I receptor (IGF-IR… Expand
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