Insulin/Insulin Receptor Signaling Pathway

Known as: Insulin signaling pathway 
Insulin binding to its receptor results in the tyrosine phosphorylation of insulin receptor substrates (IRS) by the insulin receptor tyrosine kinase… (More)
National Institutes of Health

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Highly Cited
2010
Highly Cited
2010
The livers of insulin-resistant, diabetic mice manifest selective insulin resistance, suggesting a bifurcation in the insulin… (More)
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Highly Cited
2010
Highly Cited
2010
UNLABELLED Glucagon-like peptide 1 (GLP-1) is a naturally occurring peptide secreted by the L cells of the small intestine. GLP-1… (More)
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Highly Cited
2009
Highly Cited
2009
Insulin and insulin-like growth factor I (IGF-I) are ubiquitous hormones that regulate growth and metabolism of most mammalian… (More)
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Highly Cited
2008
Highly Cited
2008
We have evaluated the effect of peripheral insulin deficiency on brain insulin pathway activity in a mouse model of type 1… (More)
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Highly Cited
2007
Highly Cited
2007
Clinical reports indicate that patients with primary aldosteronism commonly have impaired glucose tolerance; however, the… (More)
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Review
2006
Review
2006
Insulin resistant states are commonly associated with an atherogenic dyslipidemia that contributes to significantly higher risk… (More)
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Highly Cited
2004
Highly Cited
2004
The highly conserved target-of-rapamycin (TOR) protein kinases control cell growth in response to nutrients and growth factors… (More)
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Highly Cited
2004
Highly Cited
2004
In the liver, insulin controls both lipid and glucose metabolism through its cell surface receptor and intracellular mediators… (More)
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Highly Cited
2004
Highly Cited
2004
It has been suggested that serine (Ser) phosphorylation of insulin receptor substrate-1 (IRS-1) decreases the ability of IRS-1 to… (More)
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Highly Cited
2001
Highly Cited
2001
The insulin signaling pathway is activated by tyrosine phosphorylation of the insulin receptor and key post-receptor substrate… (More)
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