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Inhibition of Cellular Proliferation by Gleevec Pathway

Known as: Inhibition of Cellular Proliferation by Gleevec 
The drug Gleevec (also known as imatinib mesylate or STI-571) was approved by the FDA in 2001 for the treatment of CML, chronic myeloid leukemia… 
National Institutes of Health

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AKT1 wt AlleleBAD wt AlleleBCR protein, humanBCR wt Allele

Papers overview

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2016
2016
Abstract 2134: Rational design of selective MNK 1 and 2 kinase inhibitors for the treatment of blast crisis chronic myeloid leukemia patients
The marketed BCR-ABL tyrosine kinase inhibitor (TKI), imatinib (Gleevec™) is a very successful targeted anti-cancer therapy. It… 
2012
2012
Evaluation of the Expression of C-kit (CD117) in Ependymomas and Oligodendrogliomas
C-kit is a proto-oncogene located on the long arm of chromosome 4. Its product, CD117, is a specific immunohistochemical (IHQ… 
2008
2008
Differential Expression of miRNAs during the Course of Chronic Myeloid Leukemia.
Despite the high efficiency of CML therapy with tyrosine kinase inhibitor imatinib (Gleevec®, STI571), there are 20–30% of… 
2008
2008
Standardizing the Decision Process to Personalize a Therapy with a Theranostic : The Options for Test Index ( OFT i )
While the top pharmaceutical companies have all made investments at an R&D stage in biomarkers and genetics to aid drug selection… 
2008
2008
Factors relacionats amb el manteniment de la inflamació i l'oclusió vascular. Implicacions en l'evolució dels pacients amb arteritis de cèl·lules gegants.
L'arteritis de cel·lules gegants (ACG) es una vasculitis sistemica de caracter granulomatos que afecta vasos de calibre mitja i… 
2004
2004
Disruption of the Inhibitor-Of-Apoptosis Protein, Survivin, Sensitizes Bcr-abl Positive Cells to STI571 (Gleevec®)-Induced Apoptosis.
The Bcr-abl oncogene is found in cells of >95% of patients with CML and encodes a cytoplasmic protein with constitutive tyrosine… 
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