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Indomethacin

Known as: 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, Indometacinum, Indomethacin [Chemical/Ingredient] 
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug… Expand
National Institutes of Health

Papers overview

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Highly Cited
2012
Highly Cited
2012
BACKGROUND Preliminary research suggests that rectally administered nonsteroidal antiinflammatory drugs may reduce the incidence… Expand
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Highly Cited
2004
Highly Cited
2004
AbstractPurpose. To study the molecular structure of indomethacin-PVP amorphous solid dispersions and identify any specific… Expand
Highly Cited
2001
Highly Cited
2001
BACKGROUND The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe… Expand
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Highly Cited
1998
Highly Cited
1998
Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent phagocytic cells, a critical process in tissue… Expand
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Highly Cited
1995
Highly Cited
1995
Cyclooxygenases 1 and 2 (COX-1 and COX-2) are key enzymes in prostaglandin biosynthesis and the target enzymes for the widely… Expand
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Highly Cited
1993
Highly Cited
1993
In a 6-month, double-blind, placebo-controlled study, 1100 to 150 mg/d indomethacin appeared to protect mild to moderately… Expand
Highly Cited
1988
Highly Cited
1988
&NA; A method to measure cutaneous hyperalgesia to thermal stimulation in unrestrained animals is described. The testing paradigm… Expand
Highly Cited
1988
Highly Cited
1988
Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor… Expand
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Highly Cited
1983
Highly Cited
1983
Among 3559 newborn infants with birth weight less than 1750 gm, 421 developing a hemodynamically significant patent ductus… Expand
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Highly Cited
1971
Highly Cited
1971
The action of these two anti-inflammatory agents provides further support for the suggestion that some of their therapeutic… Expand