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Indomethacin
Known as:
1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-
, Indometacinum
, Indomethacin [Chemical/Ingredient]
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A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug…
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National Institutes of Health
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Related topics
Related topics
47 relations
Narrower (15)
Amuno
CP 331
DP 155
Indocid
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Broader (7)
Anti-Inflammatory Agents
Anti-Inflammatory Agents, Non-Steroidal
Cyclooxygenase Inhibitors
Gout Suppressants
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CYP2C19 protein, human
Gastrointestinal Hemorrhage
In Blood
Indomethacin 5 MG/ML Oral Suspension [Indocin]
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Papers overview
Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
2012
Highly Cited
2012
A randomized trial of rectal indomethacin to prevent post-ERCP pancreatitis.
B. Elmunzer
,
J. Scheiman
,
+28 authors
G. Cooper
New England Journal of Medicine
2012
Corpus ID: 8528236
BACKGROUND Preliminary research suggests that rectally administered nonsteroidal antiinflammatory drugs may reduce the incidence…
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Highly Cited
2001
Highly Cited
2001
Long-term effects of indomethacin prophylaxis in extremely-low-birth-weight infants.
B. Schmidt
,
Peter G. Davis
,
+6 authors
L. Wright
New England Journal of Medicine
2001
Corpus ID: 46562654
BACKGROUND The prophylactic administration of indomethacin reduces the frequency of patent ductus arteriosus and severe…
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Highly Cited
1998
Highly Cited
1998
Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF.
V. Fadok
,
D. Bratton
,
A. Konowal
,
Peter W. Freed
,
J. Westcott
,
P. Henson
Journal of Clinical Investigation
1998
Corpus ID: 7707545
Apoptosis in vivo is followed almost inevitably by rapid uptake into adjacent phagocytic cells, a critical process in tissue…
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Highly Cited
1997
Highly Cited
1997
Spectroscopic Characterization of Interactions Between PVP and Indomethacin in Amorphous Molecular Dispersions
L. Taylor
,
G. Zografi
Pharmaceutical Research
1997
Corpus ID: 19674756
AbstractPurpose. To study the molecular structure of indomethacin-PVP amorphous solid dispersions and identify any specific…
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Review
1995
Review
1995
The inflammatory response system of brain: implications for therapy of Alzheimer and other neurodegenerative diseases
P. Mcgeer
,
E. Mcgeer
Brain Research Reviews
1995
Corpus ID: 24050265
Highly Cited
1993
Highly Cited
1993
Clinical trial of indomethacin in Alzheimer's disease
J. Rogers
,
L. Kirby
,
+8 authors
F. Kogan
Neurology
1993
Corpus ID: 29537229
In a 6-month, double-blind, placebo-controlled study, 1100 to 150 mg/d indomethacin appeared to protect mild to moderately…
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Highly Cited
1988
Highly Cited
1988
Pressor effects of circulating endothelin are limited by its removal in the pulmonary circulation and by the release of prostacyclin and endothelium-derived relaxing factor.
G. Nucci
,
R. Thomas
,
+4 authors
J. Vane
Proceedings of the National Academy of Sciences…
1988
Corpus ID: 21583778
Endothelin releases prostacyclin and thromboxane A2 from guinea pig or rat isolated lungs and endothelium-derived relaxing factor…
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Highly Cited
1987
Highly Cited
1987
A new and sensitive method for measuring thermal nociception in cutaneous hyperalgesia
Mark J F Brown
,
Sonia C. Flores
,
R. Dubner
,
Margaret K. Hargreaves
,
P. Joris
Pain
1987
Corpus ID: 19928462
Highly Cited
1987
Highly Cited
1987
The formalin test in mice: dissociation between inflammatory and non-inflammatory pain
S. Hunskaar
,
K. Hole
Pain
1987
Corpus ID: 31511006
Highly Cited
1971
Highly Cited
1971
Indomethacin and aspirin abolish prostaglandin release from the spleen.
S. Ferreira
,
S. Moncada
,
J. Vane
Nature: New biology
1971
Corpus ID: 40899098
The action of these two anti-inflammatory agents provides further support for the suggestion that some of their therapeutic…
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