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Indomethacin

Known as: 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl-, Indometacinum, Indomethacin [Chemical/Ingredient] 
A synthetic nonsteroidal indole derivative with anti-inflammatory activity and chemopreventive properties. As a nonsteroidal anti-inflammatory drug… 
National Institutes of Health

Related topics

Related topics

47 relations

Narrower (15)

AmunoCP 331DP 155Indocid

Broader (7)

Anti-Inflammatory AgentsAnti-Inflammatory Agents, Non-SteroidalCyclooxygenase InhibitorsGout Suppressants
CYP2C19 protein, humanGastrointestinal HemorrhageIn BloodIndomethacin 5 MG/ML Oral Suspension [Indocin]

Papers overview

Semantic Scholar uses AI to extract papers important to this topic.
Highly Cited
1983
Highly Cited
1983
Arachidonic acid stimulates the formation of 1,2-diacylglycerol and phosphatidic acid in human platelets. Degree of phospholipase C activation correlates with protein phosphorylation, platelet shape…
Highly Cited
1983
Highly Cited
1983
Unsaturated fatty acids as second messengers of superoxide generation by macrophages.
Highly Cited
1982
Highly Cited
1982
The stimulation of protein degradation in muscle by Ca2+ is mediated by prostaglandin E2 and does not require the calcium-activated protease.
Highly Cited
1980
Highly Cited
1980
15-hydroxy-5,8,11,13-eicosatetraenoic acid: A potent and selective inhibitor of platelet lipoxygenase.
Highly Cited
1979
Highly Cited
1979
Stimulation of phosphatidic acid production in platelets precedes the formation of arachidonate and parallels the release of serotonin.
Highly Cited
1979
Highly Cited
1979
Transient cerebral ischemia and brain prostaglandins.
Highly Cited
1977
Highly Cited
1977
Prostaglandin E2 biosynthesis by rabbit renomedullary interstitial cells in tissue culture. Mechanism of stimulation by angiotensin II, bradykinin, and arginine vasopressin.
Highly Cited
1976
Highly Cited
1976
Protein binding of drugs in uremic and normal serum: the role of endogenous binding inhibitors.
Highly Cited
1975
Highly Cited
1975
Evidence that prostaglandin is responsible for the 'rebound contraction' following stimulation of non-adrenergic, non-cholinergic ('purinergic') inhibitory nerves.
Highly Cited
1973
Highly Cited
1973
Radioimmunological assay of prostaglandin synthetase activity.
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