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In Situ Nick-End Labeling

Known as: Nick-End Labeling, In Situ, Nick End-Labeling, In Situ, In Situ Nick End Labeling 
An in situ method for detecting areas of DNA which are nicked during APOPTOSIS. Terminal deoxynucleotidyl transferase is used to add labeled dUTP, in… Expand
National Institutes of Health

Related topics

Related topics

4 relations
ApoptosisComet Assaystandards characteristics

Broader (1)

Genetic Techniques

Papers overview

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Review
2018
Review
2018
An overview of apoptosis assays detecting DNA fragmentation
Apoptosis has been recognized as a type of programmed cell death connected with characteristic morphological and biochemical… Expand
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Highly Cited
2006
Highly Cited
2006
A Global Map of p53 Transcription-Factor Binding Sites in the Human Genome
The ability to derive a whole-genome map of transcription-factor binding sites (TFBS) is crucial for elucidating gene regulatory… Expand
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Highly Cited
2001
Highly Cited
2001
Pravastatin Treatment Increases Collagen Content and Decreases Lipid Content, Inflammation, Metalloproteinases, and Cell Death in Human Carotid Plaques: Implications for Plaque Stabilization
Background —The clinical benefits of lipid lowering with statins are attributed to changes in plaque composition leading to… Expand
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Highly Cited
1999
Highly Cited
1999
Apoptotic cell death in patients with sepsis, shock, and multiple organ dysfunction.
OBJECTIVES The purpose of this study was to determine whether apoptosis is a major mechanism of cell death in patients with… Expand
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Highly Cited
1998
Highly Cited
1998
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum.
Cellular stress, particularly in response to toxic and metabolic insults that perturb function of the endoplasmic reticulum (ER… Expand
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Highly Cited
1998
Highly Cited
1998
Multistep nature of metastatic inefficiency: dormancy of solitary cells after successful extravasation and limited survival of early micrometastases.
In cancer metastasis, only a small percentage of cells released from a primary tumor successfully form distant lesions, but it is… Expand
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Highly Cited
1998
Highly Cited
1998
Activation of Proliferator-activated Receptors α and γ Induces Apoptosis of Human Monocyte-derived Macrophages*
Peroxisome proliferator-activated receptors (PPARs) have been implicated in metabolic diseases, such as obesity, diabetes, and… Expand
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Highly Cited
1998
Highly Cited
1998
Activation and Cleavage of Caspase-3 in Apoptosis Induced by Experimental Cerebral Ischemia
We examined the expression, activation, and cellular localization of caspase-3 (CPP32) using immunohistochemistry, immunoblots… Expand
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Highly Cited
1995
Highly Cited
1995
In situ detection of fragmented dna (tunel assay) fails to discriminate among apoptosis, necrosis, and autolytic cell death: A cautionary note
Detection of DNA fragments in situ using the terminal deoxyribonucleotidyl transferase (TDT)‐mediated dUTP‐digoxigenin nick end… Expand
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Highly Cited
1995
Highly Cited
1995
Retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis.
PURPOSE To investigate whether retinal ganglion cell death in experimental glaucoma and after axotomy occurs by apoptosis… Expand
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